Pengda Chen
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Explore the profile of Pengda Chen including associated specialties, affiliations and a list of published articles.
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10
Citations
1673
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Recent Articles
1.
Du Y, Xie J, Liu D, Zhao J, Chen P, He X, et al.
Cell Mol Immunol
. 2024 Nov;
22(1):40-53.
PMID: 39516355
Eukaryotic initiation factor 4 A (eIF4A) plays critical roles during translation initiation of cellular mRNAs by forming the cap-binding eIF4F complex, recruiting the 40S small ribosome subunit, and scanning the...
2.
Liao K, Chen P, Zhang M, Wang J, Hatzihristidis T, Lin X, et al.
Cell Rep
. 2024 May;
43(6):114261.
PMID: 38776224
Thymocyte development requires precise control of PI3K-Akt signaling to promote proliferation and prevent leukemia and autoimmune disorders. Here, we show that ablating individual clusters of the miR-17∼92 family has a...
3.
He X, Zhao J, Adilijiang A, Hong P, Chen P, Lin X, et al.
Cell Mol Immunol
. 2023 Jan;
20(3):277-291.
PMID: 36631557
Upon recognition of foreign antigens, naïve B cells undergo rapid activation, growth, and proliferation. How B-cell growth and proliferation are coupled with activation remains poorly understood. Combining CRISPR/Cas9-mediated functional analysis...
4.
Liu C, Ma L, Wang Y, Zhao J, Chen P, Chen X, et al.
Sci Adv
. 2021 Oct;
7(41):eabg6262.
PMID: 34623920
Molecular pathways controlling emigration of mature thymocytes from thymus to the periphery remain incompletely understood. Here, we show that T cell–specific ablation of glycogen synthase kinase 3 (GSK3) led to...
5.
Qi T, Sun M, Zhang C, Chen P, Xiao C, Chang X
Cell Rep
. 2020 Dec;
33(9):108452.
PMID: 33264617
Plasma cells provide high-affinity antibodies against invading pathogens. Although transcriptional and epigenetic mechanisms have been extensively studied for plasma cell differentiation, how these mechanisms respond to environmental cues remains largely...
6.
Chen P, Liao K, Xiao C
Nat Immunol
. 2018 Sep;
19(10):1040-1042.
PMID: 30224820
No abstract available.
7.
Jin H, Oda H, Chen P, Yang C, Zhou X, Kang S, et al.
PLoS Genet
. 2017 Feb;
13(2):e1006623.
PMID: 28241004
MicroRNAs (miRNAs) are thought to exert their functions by modulating the expression of hundreds of target genes and each to a small degree, but it remains unclear how small changes...
8.
Ma H, Pan J, Jin L, Wu J, Ren Y, Chen P, et al.
Cancer Lett
. 2016 Apr;
376(2):293-302.
PMID: 27080303
The miR-17~92 microRNA (miRNA) cluster host gene is upregulated in a broad spectrum of human cancers including colorectal cancer (CRC). Previous studies have shown that miR-17~92 promotes tumorigenesis and cancer...
9.
He W, Wan H, Hu L, Chen P, Wang X, Huang Z, et al.
Cell Res
. 2015 Nov;
25(12):1285-98.
PMID: 26611636
Inflammasome is an intracellular signaling complex of the innate immune system. Activation of inflammasomes promotes the secretion of interleukin 1β (IL-1β) and IL-18 and triggers pyroptosis. Caspase-1 and -11 (or...
10.
Chen X, Li W, Ren J, Huang D, He W, Song Y, et al.
Cell Res
. 2013 Dec;
24(1):105-21.
PMID: 24366341
Mixed lineage kinase domain-like protein (MLKL) was identified to function downstream of receptor interacting protein 3 (RIP3) in tumor necrosis factor-α (TNF)-induced necrosis (also called necroptosis). However, how MLKL functions...