Wen-Chieh Huang
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Explore the profile of Wen-Chieh Huang including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
77
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Recent Articles
1.
Hwu J, Landge D, Huang W, Horng J, Hu Y, Hwang K, et al.
J Phys Chem B
. 2025 Mar;
PMID: 40066826
This report presents our discoveries that include the successful hybridization of grafted single-walled carbon nanotubes (SWCNTs) with dsDNA to form pseudo triplex-DNA. These tubes are attached with distinctive five-membered N-containing...
2.
Generation of Quaternary Carbons in Cycloalkanones and Lactones with Arynes through a Domino Process
Hwu J, Bohara K, Kapoor M, Roy A, Lin S, Lin C, et al.
J Org Chem
. 2024 Nov;
89(24):18393-18399.
PMID: 39614987
A synthetic method was developed for the generation of a quaternary carbon center in carbonyl compounds. This innovative process involved the reaction of α-thiolate lactones and cycloalkanones with two equivalents...
3.
Hwu J, Panja A, Tsay S, Huang W, Lin S, Yeh C, et al.
Org Lett
. 2024 Nov;
26(46):9865-9870.
PMID: 39540692
An ideal codrug design should be able to control drug release, offer selectivity during drug delivery, and break down into non-toxic fragments after biodegradation. Our design incorporates d-ribofuranose as the...
4.
Huang W, Hsu C, Albu T, Yang C
J Comput Aided Mol Des
. 2024 Jul;
38(1):25.
PMID: 39014124
Adenosine deaminases acting on RNA (ADARs) are pivotal RNA-editing enzymes responsible for converting adenosine to inosine within double-stranded RNA (dsRNA). Dysregulation of ADAR1 editing activity, often arising from genetic mutations,...
5.
Gupta N, Jayakumar S, Huang W, Leyssen P, Neyts J, Bachurin S, et al.
Int J Mol Sci
. 2022 Oct;
23(20).
PMID: 36293531
The yellow fever virus (YFV) is an emerging RNA virus and has caused large outbreaks in Africa and Central and South America. The virus is often transmitted through infected mosquitoes...
6.
Hwu J, Roy A, Tsay S, Huang W, Lin C, Hwang K, et al.
Int J Mol Sci
. 2022 Jul;
23(14).
PMID: 35886992
Chikungunya virus (CHIKV) has repeatedly spread via the bite of an infected mosquito and affected more than 100 countries. The disease poses threats to public health and the economy in...
7.
Hwu J, Kapoor M, Gupta N, Tsay S, Huang W, Tan K, et al.
Eur J Med Chem
. 2022 Feb;
232:114164.
PMID: 35176562
Development of new drugs with broad-spectrum to combat RNA viruses would be beneficial to mankind but faces a great challenge. We designed and efficiently synthesized a series of quinazolin-4-amine-SCH-coumarin conjugated...
8.
Hwu J, Panja A, Jayakumar S, Tsay S, Tan K, Huang W, et al.
Molecules
. 2020 Aug;
25(17).
PMID: 32842645
The modern world has no available drugs for the treatment of enteroviruses (EV), which affect millions of people worldwide each year. The EV71 is a major causative disease for hand,...
9.
Hwu J, Roy A, Panja A, Huang W, Hu Y, Tan K, et al.
J Org Chem
. 2020 Jul;
85(15):9835-9843.
PMID: 32615761
A three-component annulation reaction was developed for the synthesis of pyrroles, a class of compounds with various properties valuable to biomedical and polymer industries. Treatment of α-silylaryl triflates, Schiff bases,...
10.
Sorrentino L, Cossu F, Milani M, Malkoc B, Huang W, Tsay S, et al.
ChemistryOpen
. 2019 Apr;
8(4):476-482.
PMID: 31011505
Inhibitors of Apoptosis Proteins (IAPs) are conserved E3-ligases that ubiquitylate substrates to prevent apoptosis and activate the NF-kB survival pathway, often deregulated in cancer. IAPs-mediated regulation of NF-kB signaling is...