Shu-Yu Lin
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Explore the profile of Shu-Yu Lin including associated specialties, affiliations and a list of published articles.
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94
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1339
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Recent Articles
1.
Generation of Quaternary Carbons in Cycloalkanones and Lactones with Arynes through a Domino Process
Hwu J, Bohara K, Kapoor M, Roy A, Lin S, Lin C, et al.
J Org Chem
. 2024 Nov;
89(24):18393-18399.
PMID: 39614987
A synthetic method was developed for the generation of a quaternary carbon center in carbonyl compounds. This innovative process involved the reaction of α-thiolate lactones and cycloalkanones with two equivalents...
2.
Hwu J, Panja A, Tsay S, Huang W, Lin S, Yeh C, et al.
Org Lett
. 2024 Nov;
26(46):9865-9870.
PMID: 39540692
An ideal codrug design should be able to control drug release, offer selectivity during drug delivery, and break down into non-toxic fragments after biodegradation. Our design incorporates d-ribofuranose as the...
3.
Tsou J, Tsou C, Wang C, Ko A, Wang Y, Liang H, et al.
J Am Chem Soc
. 2024 Nov;
146(49):33309-33315.
PMID: 39499210
Histidine modifications of proteins are broadly based on chemical methods triggering N-substitution reactions such as aza-Michael addition at histidine's moderately nucleophilic imidazole side chain. While recent studies have demonstrated chemoselective,...
4.
Lin S, Chang Y, Tien Y, Kuo Y, Chang H, Ou L, et al.
J Med Chem
. 2024 Oct;
67(21):19777-19790.
PMID: 39473174
The development of opioid analgesics with reduced adverse effects is an unmet need. In a previous study, we discovered a unique combination of BPRMU191 and morphinan antagonists that produced potent...
5.
Sung H, Li H, Huang Y, Ai C, Hsieh M, Jan H, et al.
Nat Commun
. 2024 Aug;
15(1):7402.
PMID: 39191750
During neuronal pruning, phagocytes engulf shed cellular debris to avoid inflammation and maintain tissue homeostasis. How phagocytic receptors recognize degenerating neurites had been unclear. Here, we identify two glucosyltransferases Alg8...
6.
Huang Y, Lin S, Ou L, Huang W, Chao P, Chang Y, et al.
Cell Chem Biol
. 2024 Jul;
31(11):1885-1898.e10.
PMID: 39025070
Morphinan antagonists, which block opioid effects at mu-opioid receptors, have been studied for their analgesic potential. Previous studies have suggested that these antagonists elicit analgesia with fewer adverse effects in...
7.
Singh S, Yeat N, Wang Y, Lin S, Kuo I, Wu K, et al.
Cell Death Dis
. 2024 Jul;
15(7):468.
PMID: 38956428
No abstract available.
8.
Yeh P, Liu C, Yu C, Chang Y, Lin S, Li Y, et al.
Front Pharmacol
. 2024 Jun;
15:1419044.
PMID: 38895635
Glioblastoma multiforme (GBM) is one of the most prevalent and lethal primary central nervous system malignancies. GBM is notorious for its high rates of recurrence and therapy resistance and the...
9.
Chen C, Lin P, Lai Y, Lin M, Lin S, Hsu C
Mol Cell Proteomics
. 2024 Apr;
23(5):100762.
PMID: 38608839
Protein post-translational modifications (PTMs) are crucial in plant cellular processes, particularly in protein folding and signal transduction. N-glycosylation and phosphorylation are notably significant PTMs, playing essential roles in regulating plant...
10.
Lin S, Shen Y, Chen W, Govindaraj M, Chen J
Molecules
. 2024 Jan;
29(2).
PMID: 38257222
Reactions of '-(3-methylpyridyl)oxalamide (), ,'-(3-methylpyridyl)adipoamide () and ,'-(3-methylpyridyl)sebacoamide () with tricarboxylic acids and Cu(II) salts afforded {[Cu()(1,3,5-HBTC)]·HO} (1,3,5-HBTC = 1,3,5-benzenetricarboxylic acid), , {[Cu()(1,3,5-BTC)(HO)]·6.5HO}, , [Cu()(1,3,5-HBTB)] (1,3,5-HBTB = 1,3,5-tri(4-carboxyphenyl)benzene), , [Cu()(OH)(1,3,5-BTC)],...