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Weige Zhang

Explore the profile of Weige Zhang including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 72
Citations 321
Followers 0
Related Specialties
Chemistry
Biochemistry
Pharmacology
Top 10 Co-Authors
Qi Guan
Yingliang Wu
Daiying Zuo
Kai Bao
Zengqiang Li
Zhaoshi Bai
Jingwen Xu
Huan Qi
Lan Wu
Minghuan Gao
Published In
Eur J Med Chem
Chem Biol Interact
PLoS One
Toxicol In Vitro
Sci Rep
Affiliations
Soon will be listed here.
Recent Articles
1.
Design, synthesis and biological evaluation of novel tubulin-targeting agents with a dual-mechanism for polymerization inhibition and protein degradation
Wang S, Wang J, Lu X, Liu M, Liu Y, Li M, et al.
Eur J Med Chem . 2024 May; 272:116458. PMID: 38703557
Microtubules are recognized as one of the most vital and attractive targets in anticancer therapy. The development of novel tubulin-targeting agents with a new action mechanism is imperative. Based on...
2.
The ADAM17 inhibitor ZLDI-8 sensitized hepatocellular carcinoma cells to sorafenib through Notch1-integrin β-talk
Xu C, Gao X, Ren T, Geng H, Yang K, Huang Y, et al.
Pharmacol Res . 2024 Mar; 203:107142. PMID: 38522759
ZLDI-8 is an A disintegrin and metalloproteinase domain 17 (ADAM17) inhibitor that suppresses the shedding of Notch1 to the Notch1 intracellular domain (NICD). In previous studies, we found that ZLDI-8...
3.
Structure-based approaches for the design of 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-benzo[d][1,2,3]triazoles as tubulin polymerization inhibitors
Huang M, Han H, Liu H, Liu R, Li J, Li M, et al.
Eur J Med Chem . 2024 Mar; 269:116309. PMID: 38471357
The colchicine binding site on tubulin has been widely acknowledged as an attractive target for anticancer drug exploitation. Here, we reported the structural optimization of the lead compound 4, which...
4.
Discovery of 6-aryl-2-(3,4,5-trimethoxyphenyl)thiazole[3,2-b][1,2,4]triazoles as potent tubulin polymerization inhibitors
Li N, Guan Q, Hong Y, Zhang B, Li M, Li X, et al.
Eur J Med Chem . 2023 May; 256:115402. PMID: 37182330
Tubulin/colchicine-binding site inhibitors (CBSIs) co-crystal structures play an important role in the exploration of novel small molecules for oncotherapy. Based on the analysis of the binding models of tubulin and...
5.
Chalcogen bond-assisted syn-locked scaffolds: DFT analysis and biological implications of novel tubulin inhibitors
Li L, Zou Z, Xue B, Pang B, Yang Y, Guan Q, et al.
Biochem Biophys Res Commun . 2022 Dec; 638:134-139. PMID: 36455359
A series of new tubulin inhibitors containing chalcogen bonds have been discovered. Density functional theory (DFT) analysis of the O-C-C-S torsion profile shows a preference of 0.8 kcal/mol for the...
6.
A novel tubulin inhibitor, 6h, suppresses tumor-associated angiogenesis and shows potent antitumor activity against non-small cell lung cancers
Liu Z, Huang L, Zhou T, Chang X, Yang Y, Shi Y, et al.
J Biol Chem . 2022 May; 298(7):102063. PMID: 35618020
Tumor angiogenesis is closely associated with the metastasis and progression of non-small cell lung cancer (NSCLC), a highly vascularized solid tumor. However, novel therapeutics are lacking for the treatment of...
7.
2-Methoxy-5((3,4,5-trimethosyphenyl) seleninyl) phenol causes G2/M cell cycle arrest and apoptosis in NSCLC cells through mitochondrial apoptotic pathway and MDM2 inhibition
Liu Y, Meng Y, Bian J, Liu B, Li X, Guan Q, et al.
J Biochem Mol Toxicol . 2022 Apr; 36(7):e23066. PMID: 35384151
Nonsmall cell lung cancer (NSCLC) is one of the most common malignancies and needs novel and effective chemotherapy. In this study, our purpose is to explore the anticancer effects of...
8.
Design, synthesis and biological evaluation of colchicine glycoconjugates as tubulin polymerization inhibitors
Wang Z, Liu R, Zhang X, Chang X, Gao M, Zhang S, et al.
Bioorg Med Chem . 2022 Feb; 58:116671. PMID: 35193066
A series of new colchicine glycoconjugates as tubulin polymerization inhibitors were designed by targeting strategy based on Warburg effect. All of the colchicine glycoconjugates were synthesized and then evaluated for...
9.
The anti-MDR efficacy of YAN against A549/Taxol cells is associated with its inhibition on glycolysis and is further enhanced by 2-deoxy-d-glucose
Gao M, Yang Y, Gao Y, Liu T, Guan Q, Zhou T, et al.
Chem Biol Interact . 2022 Feb; 354:109843. PMID: 35122754
Aerobic glycolysis is a hallmark of malignant tumor. Here, the hyperactive glycolysis in multidrug-resistant A549/Taxol cells was demonstrated to be essential for maintaining the vigorous cell viability and drug resistance....
10.
Novel microtubule inhibitor SQ overcomes multidrug resistance in MCF-7/ADR cells by inhibiting BCRP function and mediating apoptosis
Chang X, Liu Z, Cao S, Bian J, Zheng D, Wang N, et al.
Toxicol Appl Pharmacol . 2022 Jan; 436:115883. PMID: 35031325
The occurrence of multidrug resistance (MDR) is one of the impediments in the clinical treatment of breast cancer, and MDR breast cancer has abnormally high breast cancer resistance protein (BCRP/ABCG2)...