Wayne R Gombotz
Overview
Explore the profile of Wayne R Gombotz including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
105
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0
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Recent Articles
1.
Murphy M, Vin C, Slough M, Gombotz W, Kelley-Clarke B
Mol Ther Methods Clin Dev
. 2016 Mar;
3:16005.
PMID: 26942209
Using lentiviral vector products in clinical applications requires an accurate method for measuring transduction titer. For vectors lacking a marker gene, quantitative polymerase chain reaction is used to evaluate the...
2.
Farley D, McCloskey L, Thorne B, Tareen S, Nicolai C, Campbell D, et al.
Mol Ther Methods Clin Dev
. 2015 Jun;
2:15017.
PMID: 26029728
It is a current regulatory requirement to demonstrate absence of detectable replication-competent lentivirus (RCL) in lentiviral vector products prior to use in clinical trials. Immune Design previously described an HIV-1-based...
3.
Kim T, Mount C, Dulken B, Ramos J, Fu C, Khant H, et al.
Mol Pharm
. 2011 Nov;
9(1):135-43.
PMID: 22118658
Polymeric micelles formed by the self-assembly of amphiphilic block copolymers can be used to encapsulate hydrophobic drugs for tumor-delivery applications. Filamentous carriers with high aspect ratios offer potential advantages over...
4.
Kim T, Mount C, Gombotz W, Pun S
Biomaterials
. 2010 Jul;
31(28):7386-97.
PMID: 20598741
Doxorubicin (DOX) is an effective chemotherapeutic against a wide range of solid tumors. However, its clinical use is limited by severe side effects such as cardiotoxicity as well as inherent...
5.
Kim T, Chen Y, Mount C, Gombotz W, Li X, Pun S
Pharm Res
. 2010 Jun;
27(9):1900-13.
PMID: 20568000
Purpose: Indocyanine green (ICG), an FDA-approved near infrared (NIR) dye, has potential application as a contrast agent for tumor detection. Because ICG binds strongly to plasma proteins and exhibits aqueous,...