Walter R Perkins
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Explore the profile of Walter R Perkins including associated specialties, affiliations and a list of published articles.
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26
Citations
266
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Recent Articles
1.
Corboz M, Nguyen T, Stautberg A, Cipolla D, Perkins W, Chapman R
J Aerosol Med Pulm Drug Deliv
. 2024 Oct;
37(5):241-283.
PMID: 39388691
The Sugen 5416/hypoxia (Su/Hx) rat model of pulmonary arterial hypertension (PAH) demonstrates most of the distinguishing features of PAH in humans, including increased wall thickness and obstruction of the small...
2.
Konicek D, Plaunt A, Gharse S, Rose S, Dorfman A, Sabnis A, et al.
Pharmaceutics
. 2023 Sep;
15(9).
PMID: 37765219
The increased prevalence of pulmonary methicillin-resistant (MRSA) infection in patients living with cystic fibrosis (CF) is concerning due to a correlation with reduced life expectancy and lack of available treatment...
3.
McDonald P, Leifer F, Basso J, Lasala D, Li D, Chen K, et al.
Front Immunol
. 2023 Aug;
14:1231047.
PMID: 37638021
Rheumatoid arthritis (RA) is a painful and incurable disease characterized by chronic joint inflammation and a progressive destruction of cartilage and bone. Although current treatments have improved clinical outcomes for...
4.
Chen K, Zhang J, LaSala D, Basso J, Chun D, Zhou Y, et al.
Front Immunol
. 2023 Jul;
14:1185727.
PMID: 37441081
Neutrophils have been implicated in initiating and perpetuating systemic lupus erythematosus and the resultant kidney damage in lupus nephritis (LN) patients, in part through an excessive release of neutrophil serine...
5.
Cipolla D, Zhang J, Korkmaz B, Chalmers J, Basso J, LaSala D, et al.
Respir Res
. 2023 May;
24(1):133.
PMID: 37198686
Background: Brensocatib is an oral, selective, reversible inhibitor of dipeptidyl peptidase-1 (DPP-1), responsible for activating neutrophil serine proteases (NSPs) including neutrophil elastase (NE), proteinase 3 (PR3), and cathepsin G (CatG)....
6.
Gauani H, Baker T, Li Z, Malinin V, Perkins W, Sullivan E, et al.
Pharmaceutics
. 2023 Mar;
15(3).
PMID: 36986795
Treprostinil palmitil (TP), a prodrug of treprostinil, is being developed as an inhalation powder (TPIP) for the treatment of patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension due to...
7.
Corboz M, Plaunt A, Malinin V, Li Z, Gauani H, Chun D, et al.
J Pharmacol Exp Ther
. 2022 Dec;
383(1):103-116.
PMID: 36507843
Treprostinil palmitil (TP), a long-acting inhaled pulmonary vasodilator prodrug of treprostinil (TRE), has beneficial effects in a Sugen5416/hypoxia (Su/Hx) rat model of pulmonary arterial hypertension (PAH) that compare favorably to...
8.
Plaunt A, Rose S, Kang J, Chen K, LaSala D, Heckler R, et al.
Antimicrob Agents Chemother
. 2022 Oct;
66(11):e0125622.
PMID: 36222535
No abstract available.
9.
Corboz M, Plaunt A, Malinin V, Li Z, Gauani H, Chun D, et al.
Eur J Pharmacol
. 2021 Sep;
916:174484.
PMID: 34508752
Treprostinil palmitil (TP) is a long-acting inhaled pulmonary vasodilator prodrug of treprostinil (TRE). In this study, TP was delivered by inhalation (treprostinil palmitil inhalation suspension, TPIS) in a rat Sugen...
10.
Plaunt A, Rose S, Kang J, Chen K, LaSala D, Heckler R, et al.
Antimicrob Agents Chemother
. 2021 May;
65(7):e0031621.
PMID: 33941518
Chronic pulmonary methicillin-resistant Staphylococcus aureus (MRSA) disease in cystic fibrosis (CF) has a high probability of recurrence following treatment with standard-of-care antibiotics and represents an area of unmet need associated...