Richard W Chapman
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Explore the profile of Richard W Chapman including associated specialties, affiliations and a list of published articles.
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38
Citations
489
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Recent Articles
1.
Corboz M, Nguyen T, Stautberg A, Cipolla D, Perkins W, Chapman R
J Aerosol Med Pulm Drug Deliv
. 2024 Oct;
37(5):241-283.
PMID: 39388691
The Sugen 5416/hypoxia (Su/Hx) rat model of pulmonary arterial hypertension (PAH) demonstrates most of the distinguishing features of PAH in humans, including increased wall thickness and obstruction of the small...
2.
Corboz M, Plaunt A, Malinin V, Li Z, Gauani H, Chun D, et al.
J Pharmacol Exp Ther
. 2022 Dec;
383(1):103-116.
PMID: 36507843
Treprostinil palmitil (TP), a long-acting inhaled pulmonary vasodilator prodrug of treprostinil (TRE), has beneficial effects in a Sugen5416/hypoxia (Su/Hx) rat model of pulmonary arterial hypertension (PAH) that compare favorably to...
3.
Plaunt A, Rose S, Kang J, Chen K, LaSala D, Heckler R, et al.
Antimicrob Agents Chemother
. 2022 Oct;
66(11):e0125622.
PMID: 36222535
No abstract available.
4.
Corboz M, Plaunt A, Malinin V, Li Z, Gauani H, Chun D, et al.
Eur J Pharmacol
. 2021 Sep;
916:174484.
PMID: 34508752
Treprostinil palmitil (TP) is a long-acting inhaled pulmonary vasodilator prodrug of treprostinil (TRE). In this study, TP was delivered by inhalation (treprostinil palmitil inhalation suspension, TPIS) in a rat Sugen...
5.
Plaunt A, Rose S, Kang J, Chen K, LaSala D, Heckler R, et al.
Antimicrob Agents Chemother
. 2021 May;
65(7):e0031621.
PMID: 33941518
Chronic pulmonary methicillin-resistant Staphylococcus aureus (MRSA) disease in cystic fibrosis (CF) has a high probability of recurrence following treatment with standard-of-care antibiotics and represents an area of unmet need associated...
6.
Chapman R, Corboz M, Fernandez C, Sullivan E, Stautberg A, Plaunt A, et al.
ERJ Open Res
. 2021 Feb;
7(1).
PMID: 33614774
Cough is induced by inhaled prostacyclin analogues including treprostinil (TRE), and, at higher doses, treprostinil palmitil (TP), a prodrug of TRE. In this report, we have investigated mechanisms involved in...
7.
Chapman R, Corboz M, Malinin V, Plaunt A, Konicek D, Li Z, et al.
Pulm Pharmacol Ther
. 2021 Feb;
65:102002.
PMID: 33596473
Treprostinil (TRE) is a prostanoid analog pulmonary vasodilator drug marketed with subcutaneous, intravenous (i.v.), oral, and inhaled routes of administration for the treatment of pulmonary arterial hypertension (PAH). Due to...
8.
Plaunt A, Islam S, Macaluso T, Gauani H, Baker T, Chun D, et al.
Int J Mol Sci
. 2021 Jan;
22(2).
PMID: 33430435
Treprostinil palmitil (TP) is a prodrug of treprostinil (TRE), a pulmonary vasodilator that has been previously formulated for inhaled administration via a nebulizer. TP demonstrates a sustained presence in the...
9.
Chapman R, Li Z, Chun D, Gauani H, Malinin V, Plaunt A, et al.
Pulm Pharmacol Ther
. 2020 Dec;
66:101983.
PMID: 33346142
Background: Treprostinil palmitil (TP) is an inhaled long-acting pulmonary vasodilator prodrug of treprostinil (TRE) that has been formulated for delivery as a suspension (treprostinil palmitil inhalation suspension; TPIS) and as...
10.
Corboz M, Salvail W, Gagnon S, LaSala D, Laurent C, Salvail D, et al.
Prostaglandins Other Lipid Mediat
. 2020 Oct;
152:106486.
PMID: 33011365
Treprostinil (TRE) is a potent pulmonary vasodilator with effects on other pathological aspects of pulmonary arterial hypertension. In this study, the prostanoid receptors involved in TRE-induced relaxation of isolated rat...