Walter R Perkins
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Explore the profile of Walter R Perkins including associated specialties, affiliations and a list of published articles.
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26
Citations
266
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Recent Articles
11.
Chapman R, Corboz M, Malinin V, Plaunt A, Konicek D, Li Z, et al.
Pulm Pharmacol Ther
. 2021 Feb;
65:102002.
PMID: 33596473
Treprostinil (TRE) is a prostanoid analog pulmonary vasodilator drug marketed with subcutaneous, intravenous (i.v.), oral, and inhaled routes of administration for the treatment of pulmonary arterial hypertension (PAH). Due to...
12.
Plaunt A, Islam S, Macaluso T, Gauani H, Baker T, Chun D, et al.
Int J Mol Sci
. 2021 Jan;
22(2).
PMID: 33430435
Treprostinil palmitil (TP) is a prodrug of treprostinil (TRE), a pulmonary vasodilator that has been previously formulated for inhaled administration via a nebulizer. TP demonstrates a sustained presence in the...
13.
Chapman R, Li Z, Chun D, Gauani H, Malinin V, Plaunt A, et al.
Pulm Pharmacol Ther
. 2020 Dec;
66:101983.
PMID: 33346142
Background: Treprostinil palmitil (TP) is an inhaled long-acting pulmonary vasodilator prodrug of treprostinil (TRE) that has been formulated for delivery as a suspension (treprostinil palmitil inhalation suspension; TPIS) and as...
14.
Corboz M, Salvail W, Gagnon S, LaSala D, Laurent C, Salvail D, et al.
Prostaglandins Other Lipid Mediat
. 2020 Oct;
152:106486.
PMID: 33011365
Treprostinil (TRE) is a potent pulmonary vasodilator with effects on other pathological aspects of pulmonary arterial hypertension. In this study, the prostanoid receptors involved in TRE-induced relaxation of isolated rat...
15.
Zhang J, Leifer F, Rose S, Chun D, Thaisz J, Herr T, et al.
Front Microbiol
. 2018 Jun;
9:915.
PMID: 29867826
Non-tuberculous mycobacteria (NTM) cause pulmonary infections in patients with structural lung damage, impaired immunity, or other risk factors. Delivering antibiotics to the sites of these infections is a major hurdle...
16.
Leifer F, Konicek D, Chen K, Plaunt A, Salvail D, Laurent C, et al.
Drug Res (Stuttg)
. 2018 May;
68(11):605-614.
PMID: 29791923
Treprostinil (TRE), a prostanoid analogue approved in the USA for the treatment of pulmonary arterial hypertension, requires continuous infusion or multiple dosing sessions per day for inhaled and oral routes...
17.
Chapman R, Li Z, Corboz M, Gauani H, Plaunt A, Konicek D, et al.
Pulm Pharmacol Ther
. 2018 Feb;
49:104-111.
PMID: 29421665
INS1009 is a long acting pulmonary vasodilator prodrug of treprostinil (TRE) that is formulated in a lipid nanoparticle for inhaled delivery by nebulization. This study examined the ability of INS1009...
18.
Corboz M, Zhang J, LaSala D, DiPetrillo K, Li Z, Malinin V, et al.
Pulm Pharmacol Ther
. 2018 Feb;
49:95-103.
PMID: 29408757
Idiopathic pulmonary fibrosis is a progressive and lethal disease and while there are now two approved drugs (Esbriet and Ofev) additional effective treatments are still needed. Recently, prostacyclin analogs such...
19.
Corboz M, Li Z, Malinin V, Plaunt A, Konicek D, Leifer F, et al.
J Pharmacol Exp Ther
. 2017 Sep;
363(3):348-357.
PMID: 28904003
This article describes the preclinical pharmacology and pharmacokinetics (PK) of hexadecyl-treprostinil (C16TR), a prodrug of treprostinil (TRE), formulated in a lipid nanoparticle (LNP) for inhalation as a pulmonary vasodilator. C16TR...
20.
Malinin V, Neville M, Eagle G, Gupta R, Perkins W
Antimicrob Agents Chemother
. 2016 Aug;
60(11):6540-6549.
PMID: 27550345
Pulmonary nontuberculous mycobacterial (PNTM) infections represent a treatment challenge. Liposomal amikacin for inhalation (LAI) is a novel formulation currently in development for the treatment of PNTM infections. The pulmonary deposition...