Walter N Hittelman
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Explore the profile of Walter N Hittelman including associated specialties, affiliations and a list of published articles.
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72
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1711
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Recent Articles
1.
Alvarez de Cienfuegos A, Cheung L, Mohamedali K, Whitsett T, Winkles J, Hittelman W, et al.
J Immunother Cancer
. 2020 Sep;
8(2).
PMID: 32958685
Background: Antibody-drug conjugates are an exceptional and useful therapeutic tool for multiple diseases, particularly for cancer treatment. We previously showed that the fusion of the serine protease granzyme B (GrB),...
2.
Sarkar A, Stellrecht C, Vangapandu H, Ayres M, Kaipparettu B, Park J, et al.
Haematologica
. 2020 Feb;
106(2):495-512.
PMID: 32029507
Ataxia telangiectasia mutated (ATM), a critical DNA damage sensor with protein kinase activity,is frequently altered in human cancers including mantle cell lymphoma (MCL). Loss of ATM protein is linked to...
3.
Liu X, Jiang Y, Takata K, Nowak B, Liu C, Wood R, et al.
Mol Cancer Ther
. 2019 Sep;
18(12):2283-2295.
PMID: 31501277
Incorporation of the clinically active deoxycytidine analogue 2'--cyano-2'-deoxy-1-β-D-arabino-pentofuranosyl-cytosine (CNDAC) into DNA generates single-strand breaks that are subsequently converted to double-strand breaks (DSB). Here, we investigated the cellular manifestations of these...
4.
Cheung L, Zhao Y, Alvarez-Cienfuegos A, Mohamedali K, Cao Y, Hittelman W, et al.
J Exp Clin Cancer Res
. 2019 Aug;
38(1):332.
PMID: 31362764
Background: Immunotherapeutic approaches designed to augment T and B cell mediated killing of tumor cells has met with clinical success in recent years suggesting tremendous potential for treatment in a...
5.
Lindemann A, Patel A, Silver N, Tang L, Liu Z, Wang L, et al.
Clin Cancer Res
. 2019 Jul;
25(18):5650-5662.
PMID: 31308060
Purpose: 53 mutations are highly prevalent in head and neck squamous cell carcinoma (HNSCC) and associated with increased resistance to conventional treatment primarily consisting of chemotherapy and radiation. Restoration of...
6.
Wang L, Chen S, Ma H, Chen H, Hittelman W, Pan H
J Neurochem
. 2018 Sep;
147(4):526-540.
PMID: 30203849
Vesicular glutamate transporter-2 (VGluT2) mediates the uptake of glutamate into synaptic vesicles in neurons. Spinal cord dorsal horn interneurons are highly heterogeneous and molecularly diverse. The functional significance of VGluT2-expressing...
7.
Gadhikar M, Zhang J, Shen L, Rao X, Wang J, Zhao M, et al.
Cancer Res
. 2017 Dec;
78(3):781-797.
PMID: 29229598
Checkpoint kinase inhibitors (CHKi) exhibit striking single-agent activity in certain tumors, but the mechanisms accounting for hypersensitivity are poorly understood. We screened a panel of 49 established human head and...
8.
Delgado M, Kothari A, Hittelman W, Chambers T
J Vis Exp
. 2017 Nov;
(129).
PMID: 29155772
The ability to synchronize cells has been central to advancing our understanding of cell cycle regulation. Common techniques employed include serum deprivation; chemicals which arrest cells at different cell cycle...
9.
Mujoo K, Pandita R, Tiwari A, Charaka V, Chakraborty S, Singh D, et al.
Stem Cell Reports
. 2017 Nov;
9(5):1660-1674.
PMID: 29103969
The nitric oxide (NO)-cyclic GMP pathway contributes to human stem cell differentiation, but NO free radical production can also damage DNA, necessitating a robust DNA damage response (DDR) to ensure...
10.
Tanaka N, Patel A, Tang L, Silver N, Lindemann A, Takahashi H, et al.
Clin Cancer Res
. 2017 Aug;
23(21):6541-6554.
PMID: 28790110
The cure rate for patients with advanced head and neck squamous cell carcinoma (HNSCC) remains poor due to resistance to standard therapy primarily consisting of chemoradiation. As mutation of in...