W N Frankel
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Explore the profile of W N Frankel including associated specialties, affiliations and a list of published articles.
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82
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Recent Articles
1.
Richard C, Tanenbaum A, Audit B, Arneodo A, Khalil A, Frankel W
J Neurosci Methods
. 2015 Jan;
242:127-40.
PMID: 25549550
Background: Spike-wave discharges (SWD) found in neuroelectrical recordings are pathognomonic to absence epilepsy. The characteristic spike-wave morphology of the spike-wave complex (SWC) constituents of SWDs can be mathematically described by...
2.
Tyler A, McGarr T, Beyer B, Frankel W, Carter G
Genes Brain Behav
. 2014 Sep;
13(8):831-40.
PMID: 25251056
Absence epilepsy (AE) is a complex, heritable disease characterized by a brief disruption of normal behavior and accompanying spike-wave discharges (SWD) on the electroencephalogram. Only a handful of genes has...
3.
Letts V, Beyer B, Frankel W
Genes Brain Behav
. 2014 May;
13(6):519-26.
PMID: 24861780
Twenty-seven inbred strains of mice were tested for spike-wave discharge (SWD) activity by video-electroencephalographic recordings over a 24-h recording period. Eight strains had reproducible, frequent SWDs, including five strains (C57BLKS/J,...
4.
Oliva M, McGarr T, Beyer B, Gazina E, Kaplan D, Cordeiro L, et al.
Neurobiol Dis
. 2014 Mar;
67:180-90.
PMID: 24657915
In excitatory neurons, SCN2A (NaV1.2) and SCN8A (NaV1.6) sodium channels are enriched at the axon initial segment. NaV1.6 is implicated in several mouse models of absence epilepsy, including a missense...
5.
Wagnon J, Mahaffey C, Sun W, Yang Y, Chao H, Frankel W
Genes Brain Behav
. 2011 Jul;
10(7):765-77.
PMID: 21745337
Mice deficient for the gene encoding the RNA-binding protein CELF4 (CUGBP, ELAV-like family member 4) have a complex seizure phenotype that includes both convulsive and non-convulsive seizures, depending upon gene...
6.
Frankel W, Yang Y, Mahaffey C, Beyer B, OBrien T
Genes Brain Behav
. 2009 Jul;
8(5):568-76.
PMID: 19624305
In a chemical mutagenesis screen we identified Szt2 (seizure threshold 2) as a gene that confers low seizure threshold to mice and may also enhance epileptogenesis. The semidominant phenotype was...
7.
Tokuda S, Beyer B, Frankel W
Genes Brain Behav
. 2009 Jan;
8(3):283-9.
PMID: 19170754
Absence epilepsy is a common form of idiopathic generalized epilepsy whose etiology is poorly understood because of genetic and phenotypic heterogeneity. The inbred mouse strain C3H/He exhibits spontaneous absence seizures...
8.
Miki T, Zwingman T, Wakamori M, Lutz C, Cook S, Hosford D, et al.
Neuroscience
. 2008 Jul;
155(1):31-44.
PMID: 18597946
The calcium channel CACNA1A gene encodes the pore-forming, voltage-sensitive subunit of the voltage-dependent calcium Ca(v)2.1 type channel. Mutations in this gene have been linked to several human disorders, including familial...
9.
Nystuen A, Legare M, Shultz L, Frankel W
Neuron
. 2001 Oct;
32(2):203-12.
PMID: 11683991
Weeble mutant mice have severe locomotor instability and significant neuronal loss in the cerebellum and in the hippocampal CA1 field. Genetic mapping was used to localize the mutation to the...
10.
Hamilton B, Frankel W
Cell
. 2001 Oct;
107(1):13-6.
PMID: 11595181
Availability of the mouse genome sequence will have a major impact on the study of vertebrate evolution, mammalian biology, and animal models of human disease. Resources to explore genome biology...