Aarron T Willingham
Overview
Explore the profile of Aarron T Willingham including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
11
Citations
1944
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Kenski D, Butora G, Willingham A, Cooper A, Fu W, Qi N, et al.
Mol Ther Nucleic Acids
. 2013 Jan;
1:e5.
PMID: 23344622
Current modifications used in small interfering RNAs (siRNAs), such as 2'-methoxy (2'-OMe) and 2'-fluoro (2'-F), improve stability, specificity or immunogenic properties but do not improve potency. These modifications were previously...
2.
Chorn G, Klein-McDowell M, Zhao L, Saunders M, Flanagan W, Willingham A, et al.
RNA
. 2012 Aug;
18(10):1796-804.
PMID: 22912485
miRNAs are ∼22-nt RNAs that bind to the Argonaute family of proteins and have important regulatory roles in plants and animals. Here, we show that miRNAs exhibit targeting activity in...
3.
Fucini R, Haringsma H, Deng P, Flanagan W, Willingham A
Nucleic Acid Ther
. 2012 Apr;
22(3):205-10.
PMID: 22519815
The immune stimulation induced by short interfering RNAs (siRNAs) has been reported to be quieted or abrogated by methoxy or fluoro modifications of the 2' position of the ribose sugar....
4.
Kenski D, Willingham A, Haringsma H, Li J, Flanagan W
Nucleic Acid Ther
. 2012 Mar;
22(2):90-5.
PMID: 22400991
Endogenous and exogenous short interfering RNAs (siRNAs) require a 5'-phosphate for loading into Ago2 and cleavage of the target mRNA. We applied a synthetic 5'-phosphate to siRNA guide strands to...
5.
Haringsma H, Li J, Soriano F, Kenski D, Flanagan W, Willingham A
Nucleic Acids Res
. 2012 Jan;
40(9):4125-36.
PMID: 22253019
While RNAi has traditionally relied on RNA duplexes, early evaluation of siRNAs demonstrated activity of the guide strand in the absence of the passenger strand. However, these single strands lacked...
6.
Kenski D, Cooper A, Li J, Willingham A, Haringsma H, Young T, et al.
Nucleic Acids Res
. 2009 Nov;
38(2):660-71.
PMID: 19917641
Small interfering RNAs (siRNAs) are short, double-stranded RNAs that use the endogenous RNAi pathway to mediate gene silencing. Phosphorylation facilitates loading of a siRNA into the Ago2 complex and subsequent...
7.
Kapranov P, Cheng J, Dike S, Nix D, Duttagupta R, Willingham A, et al.
Science
. 2007 May;
316(5830):1484-8.
PMID: 17510325
Significant fractions of eukaryotic genomes give rise to RNA, much of which is unannotated and has reduced protein-coding potential. The genomic origins and the associations of human nuclear and cytosolic...
8.
Kapranov P, Willingham A, Gingeras T
Nat Rev Genet
. 2007 May;
8(6):413-23.
PMID: 17486121
Recent evidence of genome-wide transcription in several species indicates that the amount of transcription that occurs cannot be entirely accounted for by current sets of genome-wide annotations. Evidence indicates that...
9.
Willingham A, Gingeras T
Cell
. 2006 Jul;
125(7):1215-20.
PMID: 16814704
The widespread occurrence of noncoding (nc) RNAs--unannotated eukaryotic transcripts with reduced protein coding potential--suggests that they are functionally important. Study of ncRNAs is increasing our understanding of the organization and...
10.
Willingham A, Deveraux Q, Hampton G, Aza-Blanc P
Oncogene
. 2004 Nov;
23(51):8392-400.
PMID: 15517021
Cancer develops through the successive accumulation and selection of genetic and epigenetic alterations, enabling cells to survive, replicate and evade homeostatic control mechanisms such as apoptosis and antiproliferative signals. This...