W Mathias Howell
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Explore the profile of W Mathias Howell including associated specialties, affiliations and a list of published articles.
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10
Citations
223
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Recent Articles
1.
Goransson J, Ke R, Nong R, Howell W, Karman A, Grawe J, et al.
PLoS One
. 2012 Mar;
7(2):e31068.
PMID: 22383994
Detection and identification of pathogens in environmental samples for biosecurity applications are challenging due to the strict requirements on specificity, sensitivity and time. We have developed a concept for quick,...
2.
Weibrecht I, Leuchowius K, Clausson C, Conze T, Jarvius M, Howell W, et al.
Expert Rev Proteomics
. 2010 Jun;
7(3):401-9.
PMID: 20536310
An essential skill for every researcher is to learn how to select and apply the most appropriate methods for the questions they are trying to answer. With the extensive variety...
3.
Howell W, Grundberg I, Faryna M, Landegren U, Nilsson M
Nucleic Acids Res
. 2010 Jan;
38(7):e99.
PMID: 20081204
The current arsenal of molecular tools for site-directed cleavage of single-stranded DNA (ssDNA) is limited. Here, we describe a method for targeted DNA cleavage that requires only the presence of...
4.
Goransson J, Wahlby C, Isaksson M, Howell W, Jarvius J, Nilsson M
Nucleic Acids Res
. 2008 Nov;
37(1):e7.
PMID: 19033366
We present a new random array format together with a decoding scheme for targeted multiplex digital molecular analyses. DNA samples are analyzed using multiplex sets of padlock or selector probes...
5.
Howell W
Methods Mol Biol
. 2006 Jun;
335:33-41.
PMID: 16785618
Induced fluorescence resonance energy transfer (iFRET) is a variation of resonance energy transfer that is particularly well-suited for the detection of DNA hybridization. The underlying mechanism involves monitoring changes in...
6.
Sawyer S, Howell W, Brookes A
Biotechniques
. 2003 Sep;
35(2):292-6, 298.
PMID: 12951770
Genome variation provides researchers with thousands of markers with which to study human demographic history and phenotypes. Insertion-deletion (indel) polymorphism is an important and abundant form of human genome variation,...
7.
Jobs M, Howell W, Stromqvist L, Mayr T, Brookes A
Genome Res
. 2003 May;
13(5):916-24.
PMID: 12727908
Genotyping technologies need to be continually improved in terms of their flexibility, cost-efficiency, and throughput, to push forward genome variation analysis. To this end, we have leveraged the inherent simplicity...
8.
Howell W, Jobs M, Brookes A
Genome Res
. 2002 Sep;
12(9):1401-7.
PMID: 12213777
Fluorescence resonance energy transfer (FRET) is a powerful tool for detecting spatial relationships between macromolecules, one use of which is the tracking of DNA hybridization status. The process involves measuring...
9.
Evaluation of multiple presenilin 2 SNPs for association with early-onset sporadic Alzheimer disease
Howell W, Brookes A
Am J Med Genet
. 2002 Sep;
111(2):157-63.
PMID: 12210343
The presenilin genes encode proteins that modify, mediate, or perform similar functions to gamma-secretase, the enzyme responsible for converting amyloid beta precursor protein (APP) into beta-amyloid. Mutations in the presenilin...
10.
Jobs M, Howell W, Brookes A
Biotechniques
. 2002 Jun;
32(6):1322-4, 1326, 1329.
PMID: 12074163
We describe afast, low-cost, and reliable way of creating arrays from sample molecules of interest present within microformatted sample vessels (such as 1536-well microplates). The principle involves simple centrifugal transfer...