W F Bosron
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Explore the profile of W F Bosron including associated specialties, affiliations and a list of published articles.
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90
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1364
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Recent Articles
1.
Quinney S, Sanghani S, Davis W, Hurley T, Sun Z, Murry D, et al.
J Pharmacol Exp Ther
. 2005 Feb;
313(3):1011-6.
PMID: 15687373
Capecitabine is an oral prodrug of 5-fluorouracil that is indicated for the treatment of breast and colorectal cancers. A three-step in vivo-targeted activation process requiring carboxylesterases, cytidine deaminase, and thymidine...
2.
Sanghani P, Robinson H, Bennett-Lovsey R, Hurley T, Bosron W
Chem Biol Interact
. 2003 Feb;
143-144:195-200.
PMID: 12604204
Human Class III alcohol dehydrogenase (ADH), also known as glutathione-dependent formaldehyde dehydrogenase plays an important role in the formaldehyde detoxification and reduction of the nitric oxide metabolite s-nitrosoglutathione (GSNO). It...
3.
Ramchandani V, Bosron W, Li T
Pathol Biol (Paris)
. 2002 Jan;
49(9):676-82.
PMID: 11762128
The pharmacokinetics of alcohol determines the time course of alcohol concentration in blood after the ingestion of an alcoholic beverage and the degree of exposure of organs to its effects....
4.
Sanghani P, Stone C, Ray B, Pindel E, Hurley T, Bosron W
Biochemistry
. 2000 Sep;
39(35):10720-9.
PMID: 10978156
Formaldehyde, a major industrial chemical, is classified as a carcinogen because of its high reactivity with DNA. It is inactivated by oxidative metabolism to formate in humans by glutathione-dependent formaldehyde...
5.
Humerickhouse R, Lohrbach K, Li L, Bosron W, Dolan M
Cancer Res
. 2000 Mar;
60(5):1189-92.
PMID: 10728672
7-Ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxy-camptothecin (irinotecan; CPT-11) is a prodrug activated by carboxylesterase enzymes. We characterized the hydrolysis of CPT-11 by two recently identified human carboxylesterase (hCE) enzymes, hCE-1 and hCE-2. Km and...
6.
Zhang J, Burnell J, Dumaual N, Bosron W
J Pharmacol Exp Ther
. 1999 Jun;
290(1):314-8.
PMID: 10381793
Human liver carboxylesterases catalyze the hydrolysis of apolar drug or xenobiotic esters into more soluble acid and alcohol products for elimination. Two carboxylesterases, hCE-1 and hCE-2, have been purified and...
7.
Stone C, Jipping M, Hurley T, Li T, Bosron W
Biochemistry
. 1999 May;
38(18):5829-35.
PMID: 10231534
Human class I beta 3 beta 3 is one of the alcohol dehydrogenase dimers that catalyzes the reversible oxidation of ethanol. The beta 3 subunit has a Cys substitution for...
8.
Kedishvili N, Gough W, Davis W, Parsons S, Li T, Bosron W
Biochem Biophys Res Commun
. 1998 Aug;
249(1):191-6.
PMID: 9705855
All-trans retinoic acid (atRA) is a powerful morphogen synthesized in a variety of tissues. Oxidation of all-trans retinol to all-trans retinal determines the overall rate of atRA biosynthesis. This reaction...
9.
Brzezinski M, Spink B, Dean R, Berkman C, Cashman J, Bosron W
Drug Metab Dispos
. 1997 Oct;
25(9):1089-96.
PMID: 9311626
Purified human liver carboxylesterase (hCE-1) catalyzes the hydrolysis of cocaine to form benzoylecgonine, the deacetylation of heroin to form 6-acetylmorphine, and the ethanol-dependent transesterification of cocaine to form cocaethylene. In...
10.
Xie P, Parsons S, Speckhard D, Bosron W, Hurley T
J Biol Chem
. 1997 Jul;
272(30):18558-63.
PMID: 9228021
The structural determinants of substrate recognition in the human class IV, or sigmasigma, alcohol dehydrogenase (ADH) isoenzyme were examined through x-ray crystallography and site-directed mutagenesis. The crystal structure of sigmasigma...