W E Boeglin
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Explore the profile of W E Boeglin including associated specialties, affiliations and a list of published articles.
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22
Citations
621
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Recent Articles
1.
Shappell S, Manning S, Boeglin W, Guan Y, Roberts R, Davis L, et al.
Neoplasia
. 2001 Sep;
3(4):287-303.
PMID: 11571629
Recent studies in prostate tissues and especially cell lines have suggested roles for arachidonic acid (AA) metabolizing enzymes in prostate adenocarcinoma (Pca) development or progression. The goal of this study...
2.
Valmsen K, Jarving I, Boeglin W, Varvas K, Koljak R, Pehk T, et al.
Proc Natl Acad Sci U S A
. 2001 Jun;
98(14):7700-5.
PMID: 11427702
The highest concentrations of prostaglandins in nature are found in the Caribbean gorgonian Plexaura homomalla. Depending on its geographical location, this coral contains prostaglandins with typical mammalian stereochemistry (15S-hydroxy) or...
3.
Schneider C, Keeney D, Boeglin W, Brash A
Arch Biochem Biophys
. 2001 May;
386(2):268-74.
PMID: 11368351
Formation of the 12R-lipoxygenase product, 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE), has been detected previously only in human skin (Boeglin et al. (1998) Proc. Natl. Acad. Sci. USA 95, 6744). The unexpected appearance...
4.
Jisaka M, Boeglin W, Kim R, Brash A
Arch Biochem Biophys
. 2001 May;
386(2):136-42.
PMID: 11368335
The reported crystal structures of plant and animal lipoxygenases (LOX) show that the nonheme iron in the catalytic domain is ligated by three histidines, the C-terminal isoleucine, and in certain...
5.
Shappell S, Gupta R, Manning S, Whitehead R, Boeglin W, Schneider C, et al.
Cancer Res
. 2001 Feb;
61(2):497-503.
PMID: 11212240
15-Lipoxygenase (15-LOX)-2 is expressed in benign prostate secretory cells and benign prostate produces 15S-hydroxyeicosatetraenoic acid (15S-HETE) from exogenous arachidonic acid (AA). In contrast, 15S-LOX-2 and 15S-HETE formation are reduced in...
6.
Koljak R, Jarving I, Kurg R, Boeglin W, Varvas K, Valmsen K, et al.
J Biol Chem
. 2000 Nov;
276(10):7033-40.
PMID: 11085996
In vertebrates, the synthesis of prostaglandin hormones is catalyzed by cyclooxygenase (COX)-1, a constitutively expressed enzyme with physiological functions, and COX-2, induced in inflammation and cancer. Prostaglandins have been detected...
7.
Schneider C, Boeglin W, Brash A
Anal Biochem
. 2000 Nov;
287(1):186-9.
PMID: 11078601
No abstract available.
8.
Muga S, Thuillier P, Pavone A, Rundhaug J, Boeglin W, Jisaka M, et al.
Cell Growth Differ
. 2000 Aug;
11(8):447-54.
PMID: 10965849
To determine the function and mechanism of action of the 8S-lipoxygenase (8-LOX) product of arachidonic acid, 8S-hydroxyeicosatetraenoic acid (8S-HETE), which is normally synthesized only after irritation of the epidermis, transgenic...
9.
Schneider C, Boeglin W, Lai S, Cha J, Brash A
Anal Biochem
. 2000 Aug;
284(1):125-35.
PMID: 10933865
Stereospecifically (3)H-labeled substrates are useful tools in studying the mechanism of hydrogen abstractions involved in the oxygenation of polyunsaturated fatty acids. Here, we describe modified methods for the synthesis of...
10.
Brash A, Jisaka M, Boeglin W, Chang M, Keeney D, Nanney L, et al.
Adv Exp Med Biol
. 2000 Feb;
469:83-9.
PMID: 10667314
No abstract available.