A R Brash
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Explore the profile of A R Brash including associated specialties, affiliations and a list of published articles.
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Articles
137
Citations
2780
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Recent Articles
1.
Shappell S, Manning S, Boeglin W, Guan Y, Roberts R, Davis L, et al.
Neoplasia
. 2001 Sep;
3(4):287-303.
PMID: 11571629
Recent studies in prostate tissues and especially cell lines have suggested roles for arachidonic acid (AA) metabolizing enzymes in prostate adenocarcinoma (Pca) development or progression. The goal of this study...
2.
Shappell S, Keeney D, Zhang J, Page R, Olson S, Brash A
J Invest Dermatol
. 2001 Jul;
117(1):36-43.
PMID: 11442747
15-Lipoxygenase-2 has a limited tissue distribution in epithelial tissues, with mRNA detected in skin, cornea, lung, and prostate. It was originally cloned from human hair rootlets. In this study the...
3.
Valmsen K, Jarving I, Boeglin W, Varvas K, Koljak R, Pehk T, et al.
Proc Natl Acad Sci U S A
. 2001 Jun;
98(14):7700-5.
PMID: 11427702
The highest concentrations of prostaglandins in nature are found in the Caribbean gorgonian Plexaura homomalla. Depending on its geographical location, this coral contains prostaglandins with typical mammalian stereochemistry (15S-hydroxy) or...
4.
5.
Tijet N, Schneider C, Muller B, Brash A
Arch Biochem Biophys
. 2001 May;
386(2):281-9.
PMID: 11368353
A novel member of the plant cytochrome P450 CYP74 family of fatty acid hydroperoxide metabolizing enzymes has been cloned from melon fruit (Cucumis melo). The cDNA is comprised of 1,446...
6.
Schneider C, Keeney D, Boeglin W, Brash A
Arch Biochem Biophys
. 2001 May;
386(2):268-74.
PMID: 11368351
Formation of the 12R-lipoxygenase product, 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE), has been detected previously only in human skin (Boeglin et al. (1998) Proc. Natl. Acad. Sci. USA 95, 6744). The unexpected appearance...
7.
Jisaka M, Boeglin W, Kim R, Brash A
Arch Biochem Biophys
. 2001 May;
386(2):136-42.
PMID: 11368335
The reported crystal structures of plant and animal lipoxygenases (LOX) show that the nonheme iron in the catalytic domain is ligated by three histidines, the C-terminal isoleucine, and in certain...
8.
Abraham B, Sono M, Boutaud O, SHRINER A, Dawson J, Brash A, et al.
Biochemistry
. 2001 May;
40(7):2251-9.
PMID: 11329294
Coral allene oxide synthase (AOS), a hemoprotein with weak sequence homology to catalase, is the N-terminal domain of a naturally occurring fusion protein with an 8R-lipoxygenase. AOS converts 8R-hydroperoxyeicosatetraenoic acid...
9.
Schneider C, Tallman K, Porter N, Brash A
J Biol Chem
. 2001 Mar;
276(24):20831-8.
PMID: 11259420
The mechanism of formation of 4-hydroxy-2E-nonenal (4-HNE) has been a matter of debate since it was discovered as a major cytotoxic product of lipid peroxidation in 1980. Recent evidence points...
10.
Shappell S, Gupta R, Manning S, Whitehead R, Boeglin W, Schneider C, et al.
Cancer Res
. 2001 Feb;
61(2):497-503.
PMID: 11212240
15-Lipoxygenase (15-LOX)-2 is expressed in benign prostate secretory cells and benign prostate produces 15S-hydroxyeicosatetraenoic acid (15S-HETE) from exogenous arachidonic acid (AA). In contrast, 15S-LOX-2 and 15S-HETE formation are reduced in...