W C Skarnes
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Explore the profile of W C Skarnes including associated specialties, affiliations and a list of published articles.
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28
Citations
2133
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Recent Articles
1.
Kaloff C, Anastassiadis K, Ayadi A, Baldock R, Beig J, Birling M, et al.
Drug Discov Today Dis Models
. 2024 Aug;
20:3-12.
PMID: 39132094
The International Knockout Mouse Consortium (IKMC) developed high throughput gene trapping and gene targeting pipelines that produced mostly conditional mutations of more than 18,500 genes in C57BL/6N mouse embryonic stem...
2.
Yeung A, Hale C, Xia J, Tate P, Goulding D, Keane J, et al.
Sci Rep
. 2015 Mar;
5:8908.
PMID: 25752829
The ability to differentiate genetically modified mouse embryonic stem (ES) cells into functional macrophages provides a potentially attractive resource to study host-pathogen interactions without the need for animal experimentation. This...
3.
Zupicich J, Brenner S, Skarnes W
Genome Biol
. 2002 Jan;
2(12):RESEARCH0050.
PMID: 11790253
Background: Sequestration of transcription factors in the membrane is emerging as an important mechanism for the regulation of gene expression. A handful of membrane-spanning transcription factors has been previously identified...
4.
Mitchell K, Pinson K, Kelly O, Brennan J, Zupicich J, Scherz P, et al.
Nat Genet
. 2001 Jun;
28(3):241-9.
PMID: 11431694
We describe the successful application of a modified gene-trap approach, the secretory trap, to systematically analyze the functions in vivo of large numbers of genes encoding secreted and membrane proteins....
5.
Leighton P, Mitchell K, Goodrich L, Lu X, Pinson K, Scherz P, et al.
Nature
. 2001 Mar;
410(6825):174-9.
PMID: 11242070
The search to understand the mechanisms regulating brain wiring has relied on biochemical purification approaches in vertebrates and genetic approaches in invertebrates to identify molecular cues and receptors for axon...
6.
Nadeau J, Balling R, Barsh G, Beier D, Brown S, Bucan M, et al.
Science
. 2001 Mar;
291(5507):1251-5.
PMID: 11233449
No abstract available.
7.
Dionne M, Skarnes W, Harland R
Mol Cell Biol
. 2001 Jan;
21(2):636-43.
PMID: 11134349
The Dan family of transforming growth factor beta antagonists is a large, evolutionarily conserved family of proteins. Little is known about either the specificity of these antagonists or the biological...
8.
9.
Pinson K, Brennan J, Monkley S, Avery B, Skarnes W
Nature
. 2000 Oct;
407(6803):535-8.
PMID: 11029008
Wnt genes comprise a large family of secreted polypeptides that are expressed in spatially and tissue-restricted patterns during vertebrate embryonic development. Mutational analysis in mice has shown the importance of...
10.
Burgess R, Skarnes W, Sanes J
J Cell Biol
. 2000 Oct;
151(1):41-52.
PMID: 11018052
The proteoglycan agrin is required for postsynaptic differentiation at the skeletal neuromuscular junction, but is also associated with basal laminae in numerous other tissues, and with the surfaces of some...