R S Beddington
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Explore the profile of R S Beddington including associated specialties, affiliations and a list of published articles.
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54
Citations
3683
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Recent Articles
1.
Brickman J, Clements M, Tyrell R, McNay D, Woods K, Warner J, et al.
Development
. 2001 Dec;
128(24):5189-99.
PMID: 11748154
The homeobox gene Hesx1/HESX1 has been implicated in the establishment of anterior pattern in the central nervous system (CNS) in a number of vertebrate species. Its role in pituitary development...
2.
Merry C, Bullock S, Swan D, Backen A, Lyon M, Beddington R, et al.
J Biol Chem
. 2001 Jul;
276(38):35429-34.
PMID: 11457822
Heparan sulfate (HS) is a co-receptor for a number of growth factors, morphogens, and adhesion proteins. HS biosynthetic modifications may determine the strength and outcome of HS-ligand interactions. We previously...
3.
Brennan J, Lu C, Norris D, Rodriguez T, Beddington R, Robertson E
Nature
. 2001 Jun;
411(6840):965-9.
PMID: 11418863
Shortly after implantation the mouse embryo comprises three tissue layers. The founder tissue of the embryo proper, the epiblast, forms a radially symmetric cup of epithelial cells that grows in...
4.
Rodriguez T, Casey E, Harland R, Smith J, Beddington R
Dev Biol
. 2001 Jun;
234(2):304-16.
PMID: 11397001
In the mouse, embryological and genetic studies have indicated that two spatially distinct signalling centres, the anterior visceral endoderm and the node and its derivatives, are required for the correct...
5.
Martinez-Barbera J, Beddington R
Int J Dev Biol
. 2001 Apr;
45(1):327-36.
PMID: 11291863
An increasing amount of evidence suggests that in mouse there are two signalling centres required for the formation of a complete neural axis: the anterior visceral endoderm (AVE), and the...
6.
Thomas P, Dattani M, Brickman J, McNay D, Warne G, Zacharin M, et al.
Hum Mol Genet
. 2001 Jan;
10(1):39-45.
PMID: 11136712
We have previously shown that familial septo-optic dysplasia (SOD), a syndromic form of congenital hypopituitarism involving optic nerve hypoplasia and agenesis of midline brain structures, is associated with homozygosity for...
7.
Harrison S, Houzelstein D, Dunwoodie S, Beddington R
Dev Biol
. 2000 Nov;
227(2):358-72.
PMID: 11071760
We describe the identification, biochemical characterisation, and mutation of a novel mouse gene: Sp5. Sp5 encodes a protein having a C-terminal C(2)H(2) zinc finger domain closely related to that of...
8.
Dattani M, Thomas P, Brickman J, Gupta R, Wales J, Hindmarsh P, et al.
Horm Res
. 2000 Jul;
53 Suppl 1:26-33.
PMID: 10895039
Septo-optic dysplasia (SOD) is a highly variable condition characterized by midline neurological abnormalities associated with pituitary hypoplasia and optic nerve hypoplasia. The aetiology is unknown. Mutant mice, in which a...
9.
Martinez-Barbera J, Rodriguez T, Beddington R
Dev Biol
. 2000 Jul;
223(2):422-30.
PMID: 10882526
The homeobox gene Hesx1 is expressed in the anterior visceral endoderm (AVE), anterior axial mesendoderm (AME), and anterior neural ectoderm (ANE) during early mouse embryogenesis. Previous studies have shown that...
10.
Barbera J, Clements M, Thomas P, Rodriguez T, Meloy D, Kioussis D, et al.
Development
. 2000 May;
127(11):2433-45.
PMID: 10804184
The homeobox gene Hex is expressed in the anterior visceral endoderm (AVE) and rostral definitive endoderm of early mouse embryos. Later, Hex transcripts are detected in liver, thyroid and endothelial...