W C Darbonne
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Explore the profile of W C Darbonne including associated specialties, affiliations and a list of published articles.
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10
Citations
895
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Recent Articles
1.
Liu J, Moore K, Birrer M, Berlin S, Matulonis U, Infante J, et al.
Ann Oncol
. 2016 Oct;
27(11):2124-2130.
PMID: 27793850
Background: MUC16 is a tumor-specific antigen overexpressed in ovarian (OC) and pancreatic (PC) cancers. The antibody-drug conjugate (ADC), DMUC5754A, contains the humanized anti-MUC16 monoclonal antibody conjugated to the microtubule-disrupting agent,...
2.
Clemons K, Darbonne W, Curnutte J, Sobel R, Stevens D
Microbes Infect
. 2000 Sep;
2(9):997-1001.
PMID: 10967280
Histoplasma capsulatum is an important fungal pathogen in immunocompromised hosts, including AIDS patients. Experimental evidence suggests interferon-gamma (IFN) plays a role in host defense against H. capsulatum. In these studies...
3.
Walder C, Green S, Darbonne W, Mathias J, RAE J, Dinauer M, et al.
Stroke
. 1997 Nov;
28(11):2252-8.
PMID: 9368573
Background And Purpose: Free radicals account for a significant proportion of the brain damage that occurs during ischemic stroke. Using mutant mice (X-CGD) with a dysfunctional phagocytic NADPH oxidase, we...
4.
Pennica D, King K, Shaw K, Luis E, Rullamas J, Luoh S, et al.
Proc Natl Acad Sci U S A
. 1995 Feb;
92(4):1142-6.
PMID: 7862649
Heart failure continues to be a leading cause of mortality worldwide. A hallmark of this disease is dilated cardiac hypertrophy, which is accompanied by a reactivation of genes expressed in...
5.
de Sauvage F, Hass P, Spencer S, Malloy B, Gurney A, Spencer S, et al.
Nature
. 1994 Jun;
369(6481):533-8.
PMID: 8202154
Physiological platelet synthesis is thought to require the humoral activities of meg-CSF and thrombopoietin, which respectively promote proliferation and maturation of megakaryocytic cells. A meg-CSF/thrombopoietin-like protein that is present in...
6.
Horuk R, Chitnis C, Darbonne W, Colby T, Rybicki A, Hadley T, et al.
Science
. 1993 Aug;
261(5125):1182-4.
PMID: 7689250
Plasmodium vivax and P. falciparum are the major causes of human malaria, except in sub-Saharan Africa where people lack the Duffy blood group antigen, the erythrocyte receptor for P. vivax....
7.
Horuk R, Colby T, Darbonne W, Schall T, Neote K
Biochemistry
. 1993 Jun;
32(22):5733-8.
PMID: 8389192
In addition to the two human interleukin-8 (IL-8) receptors that have been cloned, IL-8RA and IL-8RB, we recently described a binding protein in human erythrocytes that binds IL-8 and monocyte...
8.
Darbonne W, Rice G, Mohler M, Apple T, Hebert C, Valente A, et al.
J Clin Invest
. 1991 Oct;
88(4):1362-9.
PMID: 1918386
IL-8 (also known as neutrophil-activating peptide 1) is recognized as a potent effector of neutrophil functions. Several different cell types that contact blood, namely T lymphocytes, monocytes, and endothelial cells,...
9.
Hebert C, Luscinskas F, Kiely J, Luis E, Darbonne W, Bennett G, et al.
J Immunol
. 1990 Nov;
145(9):3033-40.
PMID: 2212672
We have recently shown that endothelial cell-derived IL-8 inhibits neutrophil adhesion to IL1-beta-activated human umbilical vein endothelial cell monolayers. IL-8 secreted by T lymphocytes or monocytes has been characterized as...
10.
Ramakrishnan V, Sinicropi D, Dere R, Darbonne W, Bechtol K, Baker J
J Biol Chem
. 1990 Feb;
265(5):2755-62.
PMID: 2105933
Several groups have demonstrated that radioiodinated tissue-type plasminogen activator (t-PA) binds to saturable sites on human umbilical vein endothelial cells (HUVECs) in culture (Hajjar, K. A., Hamel, N. M., Harpel,...