Vyas Ramanan
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Explore the profile of Vyas Ramanan including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
643
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Recent Articles
1.
Blume S, Garg A, Marti-Mateos Y, Midha A, Chew B, Lin B, et al.
Cell
. 2025 Feb;
PMID: 39965572
We have previously demonstrated that chronic inhaled hypoxia is remarkably therapeutic in the premier animal model of mitochondrial Leigh syndrome, the Ndufs4 knockout (KO) mouse. Subsequent work has extended this...
2.
Ullman J, Mellem K, Xi Y, Ramanan V, Merritt H, Choy R, et al.
Sci Transl Med
. 2024 Jan;
16(730):eadf1691.
PMID: 38232139
Glycogen synthase 1 (GYS1), the rate-limiting enzyme in muscle glycogen synthesis, plays a central role in energy homeostasis and has been proposed as a therapeutic target in multiple glycogen storage...
3.
Fastman N, Liu Y, Ramanan V, Merritt H, Ambing E, DePaoli-Roach A, et al.
Cell Rep
. 2022 Jul;
40(1):111041.
PMID: 35793618
Glycogen is the primary energy reserve in mammals, and dysregulation of glycogen metabolism can result in glycogen storage diseases (GSDs). In muscle, glycogen synthesis is initiated by the enzymes glycogenin-1...
4.
Michailidis E, Pabon J, Xiang K, Park P, Ramanan V, Hoffmann H, et al.
Sci Rep
. 2017 Dec;
7(1):16616.
PMID: 29192196
The discovery of sodium taurocholate cotransporting polypeptide (NTCP) as the hepatitis B virus (HBV) receptor enabled researchers to create hepatoma cell lines susceptible to HBV infection. Infection in current systems,...
5.
Stevens K, Scull M, Ramanan V, Fortin C, Chaturvedi R, Knouse K, et al.
Sci Transl Med
. 2017 Jul;
9(399).
PMID: 28724577
Control of both tissue architecture and scale is a fundamental translational roadblock in tissue engineering. An experimental framework that enables investigation into how architecture and scaling may be coupled is...
6.
Jain P, Ramanan V, Schepers A, Dalvie N, Panda A, Fleming H, et al.
Angew Chem Int Ed Engl
. 2016 Aug;
55(40):12440-4.
PMID: 27554600
The ability to remotely trigger CRISPR/Cas9 activity would enable new strategies to study cellular events with greater precision and complexity. In this work, we have developed a method to photocage...
7.
Ramanan V, Trehan K, Ong M, Luna J, Hoffmann H, Espiritu C, et al.
Virology
. 2016 Apr;
494:236-47.
PMID: 27128351
Hepatitis C virus (HCV) is a positive single-stranded RNA virus of enormous global health importance, with direct-acting antiviral therapies replacing an immunostimulatory interferon-based regimen. The dynamics of HCV positive and...
8.
March S, Ramanan V, Trehan K, Ng S, Galstian A, Gural N, et al.
Nat Protoc
. 2015 Nov;
10(12):2027-53.
PMID: 26584444
The development of therapies and vaccines for human hepatropic pathogens requires robust model systems that enable the study of host-pathogen interactions. However, in vitro liver models of infection typically use...
9.
Liu J, Tourdot R, Ramanan V, Agrawal N, Radhakrishanan R
Mol Phys
. 2015 Oct;
110(11-12):1127-1137.
PMID: 26500377
The membrane-surface migration of curvature-inducing proteins in response to membrane curvature gradients has been investigated using Monte Carlo simulations of a curvilinear membrane model based on the Helfrich Hamiltonian. Consistent...
10.
Ramanan V, Shlomai A, Cox D, Schwartz R, Michailidis E, Bhatta A, et al.
Sci Rep
. 2015 Jun;
5:10833.
PMID: 26035283
Chronic hepatitis B virus (HBV) infection is prevalent, deadly, and seldom cured due to the persistence of viral episomal DNA (cccDNA) in infected cells. Newly developed genome engineering tools may...