Vivian C Hecht
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Explore the profile of Vivian C Hecht including associated specialties, affiliations and a list of published articles.
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9
Citations
704
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Recent Articles
1.
Zhang H, Moyer B, Yu V, McGivern J, Jarosh M, Werley C, et al.
SLAS Discov
. 2020 Apr;
25(5):434-446.
PMID: 32292096
The voltage-gated sodium channel Nav1.7 is a genetically validated target for pain; pharmacological blockers are promising as a new class of nonaddictive therapeutics. The search for Nav1.7 subtype selective inhibitors...
2.
Stockslager M, Shaw Bagnall J, Hecht V, Hu K, Aranda-Michel E, Payer K, et al.
Biomicrofluidics
. 2017 Dec;
11(6):064103.
PMID: 29204244
The physical characteristics of the T cell receptor (TCR)-peptide-major histocompatibility complex (pMHC) interaction are known to play a central role in determining T cell function in the initial stages of...
3.
Hosios A, Hecht V, Danai L, Johnson M, Rathmell J, Steinhauser M, et al.
Dev Cell
. 2016 Mar;
36(5):540-9.
PMID: 26954548
Cells must duplicate their mass in order to proliferate. Glucose and glutamine are the major nutrients consumed by proliferating mammalian cells, but the extent to which these and other nutrients...
4.
Hecht V, Sullivan L, Kimmerling R, Kim D, Hosios A, Stockslager M, et al.
J Cell Biol
. 2016 Feb;
212(4):439-47.
PMID: 26880201
Cytokine regulation of lymphocyte growth and proliferation is essential for matching nutrient consumption with cell state. Here, we examine how cellular biophysical changes that occur immediately after growth factor depletion...
5.
Shaw Bagnall J, Byun S, Begum S, Miyamoto D, Hecht V, Maheswaran S, et al.
Sci Rep
. 2015 Dec;
5:18542.
PMID: 26679988
The potential for circulating tumor cells (CTCs) to elucidate the process of cancer metastasis and inform clinical decision-making has made their isolation of great importance. However, CTCs are rare in...
6.
Characterizing Cellular Biophysical Responses to Stress by Relating Density, Deformability, and Size
Byun S, Hecht V, Manalis S
Biophys J
. 2015 Oct;
109(8):1565-73.
PMID: 26488647
Cellular physical properties are important indicators of specific cell states. Although changes in individual biophysical parameters, such as cell size, density, and deformability, during cellular processes have been investigated in...
7.
Bryan A, Hecht V, Shen W, Payer K, Grover W, Manalis S
Lab Chip
. 2013 Dec;
14(3):569-576.
PMID: 24296901
Cell size, measured as either volume or mass, is a fundamental indicator of cell state. Far more tightly regulated than size is density, the ratio between mass and volume, which...
8.
Feijo Delgado F, Cermak N, Hecht V, Son S, Li Y, Knudsen S, et al.
PLoS One
. 2013 Jul;
8(7):e67590.
PMID: 23844039
We present a method for direct non-optical quantification of dry mass, dry density and water mass of single living cells in suspension. Dry mass and dry density are obtained simultaneously...
9.
Byun S, Son S, Amodei D, Cermak N, Shaw J, Kang J, et al.
Proc Natl Acad Sci U S A
. 2013 Apr;
110(19):7580-5.
PMID: 23610435
Metastasis requires the penetration of cancer cells through tight spaces, which is mediated by the physical properties of the cells as well as their interactions with the confined environment. Various...