Robert J Kimmerling
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Explore the profile of Robert J Kimmerling including associated specialties, affiliations and a list of published articles.
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16
Citations
368
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Recent Articles
1.
Winter P, Ramseier M, Navia A, Saksena S, Strouf H, Senhaji N, et al.
bioRxiv
. 2024 Jun;
PMID: 38915726
Efforts to cure BCR::ABL1 B cell acute lymphoblastic leukemia (Ph+ ALL) solely through inhibition of ABL1 kinase activity have thus far been insufficient despite the availability of tyrosine kinase inhibitors...
2.
Stevens M, Kimmerling R, Olcum S, Vacha M, LaBella R, Minnah A, et al.
JCO Precis Oncol
. 2024 Jan;
8:e2300349.
PMID: 38237098
Purpose: Cancer patients with advanced-stage disease have poor prognosis, typically having limited options for efficacious treatment, and genomics-based therapy guidance continues to benefit only a fraction of patients. Next-generation ex...
3.
Kimmerling R, Stevens M, Olcum S, Minnah A, Vacha M, LaBella R, et al.
Commun Biol
. 2023 Jan;
6(1):15.
PMID: 36609595
No abstract available.
4.
Kimmerling R, Stevens M, Olcum S, Minnah A, Vacha M, LaBella R, et al.
Commun Biol
. 2022 Nov;
5(1):1295.
PMID: 36435843
Functional precision medicine offers a promising complement to genomics-based cancer therapy guidance by testing drug efficacy directly on a patient's tumor cells. Here, we describe a workflow that utilizes single-cell...
5.
Mu L, Kang J, Olcum S, Payer K, Calistri N, Kimmerling R, et al.
Proc Natl Acad Sci U S A
. 2020 Jun;
117(27):15659-15665.
PMID: 32581119
Cell size is believed to influence cell growth and metabolism. Consistently, several studies have revealed that large cells have lower mass accumulation rates per unit mass (i.e., growth efficiency) than...
6.
Stockslager M, Olcum S, Knudsen S, Kimmerling R, Cermak N, Payer K, et al.
Rev Sci Instrum
. 2019 Sep;
90(8):085004.
PMID: 31472632
Measuring the size of micron-scale particles plays a central role in the biological sciences and in a wide range of industrial processes. A variety of size parameters, such as particle...
7.
Kimmerling R, Prakadan S, Gupta A, Calistri N, Stevens M, Olcum S, et al.
Genome Biol
. 2018 Nov;
19(1):207.
PMID: 30482222
Mass and growth rate are highly integrative measures of cell physiology not discernable via genomic measurements. Here, we introduce a microfluidic platform enabling direct measurement of single-cell mass and growth...
8.
Quantification of somatic mutation flow across individual cell division events by lineage sequencing
Brody Y, Kimmerling R, Maruvka Y, Benjamin D, Elacqua J, Haradhvala N, et al.
Genome Res
. 2018 Nov;
28(12):1901-1918.
PMID: 30459213
Mutation data reveal the dynamic equilibrium between DNA damage and repair processes in cells and are indispensable to the understanding of age-related diseases, tumor evolution, and the acquisition of drug...
9.
Calistri N, Kimmerling R, Malinowski S, Touat M, Stevens M, Olcum S, et al.
Nat Commun
. 2018 Nov;
9(1):4784.
PMID: 30429479
A fundamental trade-off between flow rate and measurement precision limits performance of many single-cell detection strategies, especially for applications that require biophysical measurements from living cells within complex and low-input...
10.
Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression
Mowery C, Reyes J, Cabal-Hierro L, Higby K, Karlin K, Wang J, et al.
Cell Rep
. 2018 Nov;
25(7):1898-1911.e5.
PMID: 30428356
Down syndrome (DS, trisomy 21) is associated with developmental abnormalities and increased leukemia risk. To reconcile chromatin alterations with transcriptome changes, we performed paired exogenous spike-in normalized RNA and chromatin...