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Virginia Pierini

Explore the profile of Virginia Pierini including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 125
Followers 0
Related Specialties
Biochemistry
Microbiology
Infectious Diseases
Top 10 Co-Authors
Oliver T Fackler
Massimo Pizzato
Birthe Trautz
Jan Kranich
Alessia Ruggieri
Christian Luchtenborg
Britta Brugger
Hans-Georg Krausslich
Barbel Glass
Oliver T Keppler
Published In
J Virol
J Biol Chem
J Innate Immun
J Acquir Immune Defic Syndr
J Gen Virol
Affiliations
Soon will be listed here.
Recent Articles
1.
SERINC5 Can Enhance Proinflammatory Cytokine Production by Primary Human Myeloid Cells in Response to Challenge with HIV-1 Particles
Pierini V, Gallucci L, Sturzel C, Kirchhoff F, Fackler O
J Virol . 2021 Feb; 95(9). PMID: 33597208
HIV-1 has to overcome physical barriers posed by host cell restriction factors (RFs) for efficient replication. Some RFs, including Trim5α and tetherin, trigger antiviral signaling in addition to directly impairing...
2.
Patient-Derived HIV-1 Nef Alleles Reveal Uncoupling of CD4 Downregulation and SERINC5 Antagonism Functions of the Viral Pathogenesis Factor
Obermaier B, Ananth S, Tibroni N, Pierini V, Shytaj I, Diaz R, et al.
J Acquir Immune Defic Syndr . 2020 Jun; 85(2):e23-e26. PMID: 32541384
No abstract available.
3.
SERINC5 Is an Unconventional HIV Restriction Factor That Is Upregulated during Myeloid Cell Differentiation
Zutz A, Scholz C, Schneider S, Pierini V, Munchhoff M, Sutter K, et al.
J Innate Immun . 2020 Jan; 12(5):399-409. PMID: 31935717
Classical antiviral restriction factors promote cellular immunity by their ability to interfere with virus replication and induction of their expression by proinflammatory cytokines such as interferons. The serine incorporator proteins...
4.
Correction: The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles
Trautz B, Wiedemann H, Luchtenborg C, Pierini V, Kranich J, Glass B, et al.
J Biol Chem . 2019 Dec; 294(49):18951. PMID: 31811051
No abstract available.
5.
The antiviral activity of rodent and lagomorph SERINC3 and SERINC5 is counteracted by known viral antagonists
de Sousa-Pereira P, Abrantes J, Bauernfried S, Pierini V, Esteves P, Keppler O, et al.
J Gen Virol . 2018 Dec; 100(2):278-288. PMID: 30566072
A first step towards the development of a human immunodeficiency virus (HIV) animal model has been the identification and surmounting of species-specific barriers encountered by HIV along its replication cycle...
6.
The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles
Trautz B, Wiedemann H, Luchtenborg C, Pierini V, Kranich J, Glass B, et al.
J Biol Chem . 2017 Jun; 292(33):13702-13713. PMID: 28659343
The host-cell restriction factor SERINC5 potently suppresses the infectivity of HIV, type 1 (HIV-1) particles, and is counteracted by the viral pathogenesis factor Nef. However, the molecular mechanism by which...
7.
The Antagonism of HIV-1 Nef to SERINC5 Particle Infectivity Restriction Involves the Counteraction of Virion-Associated Pools of the Restriction Factor
Trautz B, Pierini V, Wombacher R, Stolp B, Chase A, Pizzato M, et al.
J Virol . 2016 Sep; 90(23):10915-10927. PMID: 27681140
Importance: HIV-1 Nef critically determines virus spread and disease progression in infected individuals by incompletely defined mechanisms. SERINC3 and SERINC5 were recently identified as potent inhibitors of HIV particle infectivity...