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Patient-Derived HIV-1 Nef Alleles Reveal Uncoupling of CD4 Downregulation and SERINC5 Antagonism Functions of the Viral Pathogenesis Factor

Overview
Journal J Acquir Immune Defic Syndr
Specialty Infectious Diseases
Date 2020 Jun 17
PMID 32541384
Citations 5
Authors
Benedikt Obermaier
Swetha Ananth
Nadine Tibroni
Virginia Pierini
Iart L Shytaj
Ricardo S Diaz
Marina Lusic
Oliver T Fackler
Affiliations
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A Conserved Acidic Residue in the C-Terminal Flexible Loop of HIV-1 Nef Contributes to the Activity of SERINC5 and CD4 Downregulation.

Firrito C, Bertelli C, Rosa A, Chande A, Ananth S, van Dijk H Viruses. 2023; 15(3).

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An Amino Acid Polymorphism within the HIV-1 Nef Dileucine Motif Functionally Uncouples Cell Surface CD4 and SERINC5 Downregulation.

Mumby M, Johnson A, Trothen S, Edgar C, Gibson R, Stathopulos P J Virol. 2021; 95(16):e0058821.

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Nef Obtained from Individuals with HIV-1 Vary in Their Ability to Antagonize SERINC3- and SERINC5-Mediated HIV-1 Restriction.

Kruize Z, van Nuenen A, van Wijk S, Girigorie A, van Dort K, Booiman T Viruses. 2021; 13(3).

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SERINC5 Can Enhance Proinflammatory Cytokine Production by Primary Human Myeloid Cells in Response to Challenge with HIV-1 Particles.

Pierini V, Gallucci L, Sturzel C, Kirchhoff F, Fackler O J Virol. 2021; 95(9).

PMID: 33597208 PMC: 8104095. DOI: 10.1128/JVI.02372-20.