Vineet Bafna
Overview
Explore the profile of Vineet Bafna including associated specialties, affiliations and a list of published articles.
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Articles
173
Citations
8507
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Recent Articles
1.
Lv W, Zeng Y, Li C, Liang Y, Tao H, Zhu Y, et al.
Cancer Discov
. 2025 Mar;
PMID: 40062518
Extrachromosomal DNA (ecDNA) presents a promising target for cancer therapy; however, its spatial-temporal diversity and influence on tumor evolution and the immune microenvironment remain largely unclear. We apply computational methods...
2.
Dehkordi S, Jia Z, Estabrook J, Hauenstein J, Miller N, Guleray-Lafci N, et al.
medRxiv
. 2025 Feb;
PMID: 39990584
The whole genome karyotype refers to the sequence of large chromosomal segments that make up an individual's genotype. karyotype analysis, which includes descriptions of aneuploidies and other rearrangements is crucial...
3.
Dehkordi S, Wong I, Ni J, Luebeck J, Zhu K, Prasad G, et al.
Nat Commun
. 2025 Feb;
16(1):1497.
PMID: 39929823
Oncogene amplification is a key driver of cancer pathogenesis. Both breakage fusion bridge (BFB) cycles and extrachromosomal DNA (ecDNA) can lead to high oncogene copy numbers, but the impact of...
4.
Pradella D, Zhang M, Gao R, Yao M, Gluchowska K, Cendon-Florez Y, et al.
Nature
. 2024 Dec;
637(8047):955-964.
PMID: 39695225
Focal gene amplifications are among the most common cancer-associated mutations but have proven challenging to engineer in primary cells and model organisms. Here we describe a general strategy to engineer...
5.
Tang J, Weiser N, Wang G, Chowdhry S, Curtis E, Zhao Y, et al.
Nature
. 2024 Nov;
635(8037):210-218.
PMID: 39506153
Extrachromosomal DNA (ecDNA) presents a major challenge for cancer patients. ecDNA renders tumours treatment resistant by facilitating massive oncogene transcription and rapid genome evolution, contributing to poor patient survival. At...
6.
Hung K, Jones M, Wong I, Curtis E, Lange J, He B, et al.
Nature
. 2024 Nov;
635(8037):201-209.
PMID: 39506152
The chromosomal theory of inheritance dictates that genes on the same chromosome segregate together while genes on different chromosomes assort independently. Extrachromosomal DNAs (ecDNAs) are common in cancer and drive...
7.
Bailey C, Pich O, Thol K, Watkins T, Luebeck J, Rowan A, et al.
Nature
. 2024 Nov;
635(8037):193-200.
PMID: 39506150
Extrachromosomal DNA (ecDNA) is a major contributor to treatment resistance and poor outcome for patients with cancer. Here we examine the diversity of ecDNA elements across cancer, revealing the associated...
8.
Noorani I, Haughey M, Luebeck J, Rowan A, Gronroos E, Terenzi F, et al.
bioRxiv
. 2024 Nov;
PMID: 39484416
Highlights: ecDNA is the most common mechanism of focal oncogene amplification in wt glioblastoma. and its variants on ecDNA are particularly potent, likely arising early in tumor development, providing a...
9.
Kim H, Kim S, Wade T, Yeo E, Lipsa A, Golebiewska A, et al.
Nat Genet
. 2024 Oct;
56(11):2447-2454.
PMID: 39402156
To understand the role of extrachromosomal DNA (ecDNA) amplifications in cancer progression, we detected and classified focal amplifications in 8,060 newly diagnosed primary cancers, untreated metastases and heavily pretreated tumors....
10.
Kraft K, Murphy S, Jones M, Shi Q, Bhargava-Shah A, Luong C, et al.
bioRxiv
. 2024 Sep;
PMID: 39282372
Extrachromosomal DNA (ecDNA) is a hallmark of aggressive cancer, contributing to both oncogene amplification and tumor heterogeneity. Here, we used Hi-C, super-resolution imaging, and long-read sequencing to explore the nuclear...