Utkrisht Rajkumar
Overview
Explore the profile of Utkrisht Rajkumar including associated specialties, affiliations and a list of published articles.
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10
Citations
821
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Recent Articles
1.
Dehkordi S, Wong I, Ni J, Luebeck J, Zhu K, Prasad G, et al.
Nat Commun
. 2025 Feb;
16(1):1497.
PMID: 39929823
Oncogene amplification is a key driver of cancer pathogenesis. Both breakage fusion bridge (BFB) cycles and extrachromosomal DNA (ecDNA) can lead to high oncogene copy numbers, but the impact of...
2.
Dehkordi S, Wong I, Ni J, Luebeck J, Zhu K, Prasad G, et al.
bioRxiv
. 2024 Jan;
PMID: 38168210
Oncogene amplification is a major driver of cancer pathogenesis. Breakage fusion bridge (BFB) cycles, like extrachromosomal DNA (ecDNA), can lead to high copy numbers of oncogenes, but their impact on...
3.
Chapman O, Luebeck J, Sridhar S, Wong I, Dixit D, Wang S, et al.
Nat Genet
. 2023 Nov;
55(12):2189-2199.
PMID: 37945900
Circular extrachromosomal DNA (ecDNA) in patient tumors is an important driver of oncogenic gene expression, evolution of drug resistance and poor patient outcomes. Applying computational methods for the detection and...
4.
Lange J, Rose J, Chen C, Pichugin Y, Xie L, Tang J, et al.
Nat Genet
. 2022 Sep;
54(10):1527-1533.
PMID: 36123406
Oncogene amplification on extrachromosomal DNA (ecDNA) is a common event, driving aggressive tumor growth, drug resistance and shorter survival. Currently, the impact of nonchromosomal oncogene inheritance-random identity by descent-is poorly...
5.
Javadzadeh S, Rajkumar U, Nguyen N, Sarmashghi S, Luebeck J, Shang J, et al.
NAR Genom Bioinform
. 2022 May;
4(2):lqac032.
PMID: 35493723
DNA viruses are important infectious agents known to mediate a large number of human diseases, including cancer. Viral integration into the host genome and the formation of hybrid transcripts are...
6.
Hung K, Yost K, Xie L, Shi Q, Helmsauer K, Luebeck J, et al.
Nature
. 2021 Nov;
600(7890):731-736.
PMID: 34819668
Extrachromosomal DNA (ecDNA) is prevalent in human cancers and mediates high expression of oncogenes through gene amplification and altered gene regulation. Gene induction typically involves cis-regulatory elements that contact and...
7.
Luebeck J, Coruh C, Dehkordi S, Lange J, Turner K, Deshpande V, et al.
Nat Commun
. 2020 Sep;
11(1):4374.
PMID: 32873787
Oncogene amplification, a major driver of cancer pathogenicity, is often mediated through focal amplification of genomic segments. Recent results implicate extrachromosomal DNA (ecDNA) as the primary driver of focal copy...
8.
Kim H, Nguyen N, Turner K, Wu S, Gujar A, Luebeck J, et al.
Nat Genet
. 2020 Aug;
52(9):891-897.
PMID: 32807987
Extrachromosomal DNA (ecDNA) amplification promotes intratumoral genetic heterogeneity and accelerated tumor evolution; however, its frequency and clinical impact are unclear. Using computational analysis of whole-genome sequencing data from 3,212 cancer...
9.
Wu S, Turner K, Nguyen N, Raviram R, Erb M, Santini J, et al.
Nature
. 2019 Nov;
575(7784):699-703.
PMID: 31748743
Oncogenes are commonly amplified on particles of extrachromosomal DNA (ecDNA) in cancer, but our understanding of the structure of ecDNA and its effect on gene regulation is limited. Here, by...
10.
Rajkumar U, Turner K, Luebeck J, Deshpande V, Chandraker M, Mischel P, et al.
iScience
. 2019 Nov;
21:428-435.
PMID: 31706138
Oncogene amplification is one of the most common drivers of genetic events in cancer, potently promoting tumor development, growth, and progression. The recent discovery that oncogene amplification commonly occurs on...