Vincent Stroobant
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Explore the profile of Vincent Stroobant including associated specialties, affiliations and a list of published articles.
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83
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3668
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Recent Articles
11.
Kozlova A, Thabault L, Liberelle M, Klaessens S, Prevost J, Mathieu C, et al.
J Med Chem
. 2021 Aug;
64(15):10967-10980.
PMID: 34338527
Tryptophan 2,3-dioxygenase (TDO2) is a heme-containing enzyme constitutively expressed at high concentrations in the liver and responsible for l-tryptophan (l-Trp) homeostasis. Expression of TDO2 in cancer cells results in the...
12.
Klaessens S, Stroobant V, Hoffmann D, Gyrd-Hansen M, Pilotte L, Vigneron N, et al.
Proc Natl Acad Sci U S A
. 2021 Jun;
118(23).
PMID: 34074763
Maintaining stable tryptophan levels is required to control neuronal and immune activity. We report that tryptophan homeostasis is largely controlled by the stability of tryptophan 2,3-dioxygenase (TDO), the hepatic enzyme...
13.
Levy T, Marchand L, Stroobant V, Pilotte L, Van den Eynde B, Rodriguez F, et al.
Bioorg Med Chem Lett
. 2021 Mar;
40:127910.
PMID: 33711443
Indoleamine 2,3-dioxygenase (IDO1) and tryptophane 2,3-dioxygenase (TDO) are two heme-containing enzymes which catalyze the conversion of tryptophan to N-formylkynurenine. Both enzymes are well establish therapeutic targets as important factors in...
14.
Hoffmann D, Dvorakova T, Schramme F, Stroobant V, Van den Eynde B
Front Immunol
. 2020 Dec;
11:601759.
PMID: 33363543
Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) catalyze the rate-limiting step of tryptophan catabolism along the kynurenine pathway, which has important immuno suppressive properties, particularly in tumor cells and...
15.
Abi Habib J, De Plaen E, Stroobant V, Zivkovic D, Bousquet M, Guillaume B, et al.
Sci Rep
. 2020 Sep;
10(1):15765.
PMID: 32978409
The proteasome is responsible for selective degradation of proteins. It exists in mammalian cells under four main subtypes, which differ by the combination of their catalytic subunits: the standard proteasome...
16.
Assi M, Pirlot B, Stroobant V, Thissen J, Jacquemin P
Int J Mol Sci
. 2020 Sep;
21(17).
PMID: 32887255
KRAS is a powerful oncogene responsible for the development of many cancers. Despite the great progress in understanding its function during the last decade, the study of KRAS expression, subcellular...
17.
Hoffmann D, Pilotte L, Stroobant V, Van den Eynde B
Int J Tryptophan Res
. 2020 Jan;
12:1178646919891736.
PMID: 31903023
Tumor-associated macrophages are immune cells with diverse functions in tumor development. Among other functions, they downregulate immune-mediated tumor rejection by depriving lymphocytes of nutrients. The essential amino acid tryptophan is...
18.
Hoffmann D, Dvorakova T, Stroobant V, Bouzin C, Daumerie A, Solvay M, et al.
Cancer Immunol Res
. 2019 Dec;
8(1):19-31.
PMID: 31806639
Tryptophan catabolism is used by tumors to resist immune attack. It can be catalyzed by indoleamine 2,3-dioxygenase (IDO1) and tryptophan 2,3-dioxygenase (TDO). IDO1 is frequently expressed in tumors and has...
19.
Schramme F, Crosignani S, Frederix K, Hoffmann D, Pilotte L, Stroobant V, et al.
Cancer Immunol Res
. 2019 Dec;
8(1):32-45.
PMID: 31806638
Tryptophan 2,3-dioxygenase (TDO) is an enzyme that degrades tryptophan into kynurenine and thereby induces immunosuppression. Like indoleamine 2,3-dioxygenase (IDO1), TDO is considered as a relevant drug target to improve the...
20.
Choumessi A, Johanns M, Beaufay C, Herent M, Stroobant V, Vertommen D, et al.
Biochem J
. 2019 Nov;
476(24):3687-3704.
PMID: 31782497
Root extracts of a Cameroon medicinal plant, Dorstenia psilurus, were purified by screening for AMP-activated protein kinase (AMPK) activation in incubated mouse embryo fibroblasts (MEFs). Two isoprenylated flavones that activated...