Pierre van der Bruggen
Overview
Explore the profile of Pierre van der Bruggen including associated specialties, affiliations and a list of published articles.
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77
Citations
3374
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Recent Articles
1.
Delhez N, Aboubakar Nana F, Houbion C, Bayard A, Bruger A, Vanhaver C, et al.
Methods Cell Biol
. 2025 Jan;
191():151-196.
PMID: 39824555
Neutrophils were historically considered a homogenous population of cells with functions limited to innate immunity against external threats. However, with the rise of immunotherapy, recent works have shown that neutrophils...
2.
Hirsch T, Neyens D, Duhamel C, Bayard A, Vanhaver C, Luyckx M, et al.
Cell Rep
. 2024 Jun;
43(7):114401.
PMID: 38943641
Human CD8 tumor-infiltrating lymphocytes (TILs) with impaired effector functions and PD-1 expression are categorized as exhausted. However, the exhaustion-like features reported in TILs might stem from their activation rather than...
3.
Neyens D, Hirsch T, Abdel Aziz Issa Abdel Hadi A, Dauguet N, Vanhaver C, Bayard A, et al.
Front Immunol
. 2024 Jan;
14:1308539.
PMID: 38187391
Introduction: The transcription factor HELIOS is primarily known for its expression in CD4 regulatory T cells, both in humans and mice. In mice, HELIOS is found in exhausted CD8 T...
4.
Immunosuppressive low-density neutrophils in the blood of cancer patients display a mature phenotype
Vanhaver C, Aboubakar Nana F, Delhez N, Luyckx M, Hirsch T, Bayard A, et al.
Life Sci Alliance
. 2023 Nov;
7(1).
PMID: 37931958
The presence of human neutrophils in the tumor microenvironment is strongly correlated to poor overall survival. Most previous studies have focused on the immunosuppressive capacities of low-density neutrophils (LDN), also...
5.
Vanhaver C, van der Bruggen P, Bruger A
J Clin Med
. 2021 Jul;
10(13).
PMID: 34203451
Myeloid-derived suppressor cells (MDSCs) expand during pathological conditions in both humans and mice and their presence is linked to poor clinical outcomes for cancer patients. Studying MDSC immunosuppression is restricted...
6.
Gondois-Rey F, Paul M, Alcaraz F, Bourass S, Monnier J, Malissen N, et al.
Cancers (Basel)
. 2021 Apr;
13(6).
PMID: 33802925
PMN-MDSCs support tumor progression and resistance to ICI therapy through their suppressive functions but their heterogeneity limits their use as biomarkers in cancer. Our aim was to investigate the phenotypic...
7.
A Genetic Vaccine Encoding Shared Cancer Neoantigens to Treat Tumors with Microsatellite Instability
Leoni G, DAlise A, Cotugno G, Langone F, Garzia I, De Lucia M, et al.
Cancer Res
. 2020 Jul;
80(18):3972-3982.
PMID: 32690723
Tumors with microsatellite instability (MSI) are caused by a defective DNA mismatch repair system that leads to the accumulation of mutations within microsatellite regions. Indels in microsatellites of coding genes...
8.
Renard H, Tyckaert F, Lo Giudice C, Hirsch T, Valades-Cruz C, Lemaigre C, et al.
Nat Commun
. 2020 Mar;
11(1):1457.
PMID: 32193381
While several clathrin-independent endocytic processes have been described so far, their biological relevance often remains elusive, especially in pathophysiological contexts such as cancer. In this study, we find that the...
9.
Bruger A, Vanhaver C, Bruderek K, Amodio G, Tavukcuoglu E, Esendagli G, et al.
Methods Enzymol
. 2020 Feb;
632:155-192.
PMID: 32000895
Inhibition of T-cell proliferation is the most common approach to assess human myeloid-derived suppressor cell (MDSC) functions. However, diverse methodologies hinder the comparison of results obtained in different laboratories. In...
10.
Vanhaver C, Gordon-Alonso M, Bayard A, Catanese M, Colau D, van der Bruggen P, et al.
Methods Enzymol
. 2020 Jan;
631:159-194.
PMID: 31948546
Recent advances in next generation sequencing expanded the availability of tumor mutanome data that list the mutations present in cancer cells. Mutated proteins are an interesting source of neoantigens that...