Vincent P Schulz
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Explore the profile of Vincent P Schulz including associated specialties, affiliations and a list of published articles.
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38
Citations
1511
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Recent Articles
1.
Gu S, Butt A, Schulz V, Rinder H, Lee A, Gallagher P, et al.
Blood Cells Mol Dis
. 2024 Sep;
110:102893.
PMID: 39260211
Inherited platelet disorders (IPDs) are a heterogeneous group of conditions that present significant challenges in diagnosis and management. Here, we report two cases of patients presenting with clinically significant bleeding...
2.
McGrath K, Koniski A, Murphy K, Getman M, An H, Schulz V, et al.
bioRxiv
. 2024 Feb;
PMID: 38370741
The limited proliferative capacity of erythroid precursors is a major obstacle to generate sufficient numbers of in vitro-derived red blood cells (RBC) for clinical purposes. We and others have determined...
3.
Chakraborty R, Ostriker A, Xie Y, Dave J, Gamez-Mendez A, Chatterjee P, et al.
Circulation
. 2022 May;
145(23):1720-1737.
PMID: 35502657
Background: Vascular smooth muscle cell (VSMC) phenotypic switching contributes to cardiovascular diseases. Epigenetic regulation is emerging as a key regulatory mechanism, with the methylcytosine dioxygenase TET2 acting as a master...
4.
Murphy Z, Murphy K, Myers J, Getman M, Couch T, Schulz V, et al.
Blood
. 2021 Jun;
138(18):1740-1756.
PMID: 34075391
The terminal maturation of human erythroblasts requires significant changes in gene expression in the context of dramatic nuclear condensation. Defects in this process are associated with inherited anemias and myelodysplastic...
5.
Wang Y, Li W, Schulz V, Zhao H, Qu X, Qi Q, et al.
Blood
. 2021 May;
138(17):1615-1627.
PMID: 34036344
Histone deacetylases (HDACs) are a group of enzymes that catalyze the removal of acetyl groups from histone and nonhistone proteins. HDACs have been shown to have diverse functions in a...
6.
Gautier E, Leduc M, Ladli M, Schulz V, Lefevre C, Boussaid I, et al.
Blood Adv
. 2020 Apr;
4(7):1464-1477.
PMID: 32282884
Murine-based cellular models have provided and continue to provide many useful insights into the fundamental mechanisms of erythropoiesis, as well as insights into the pathophysiology of inherited and acquired red...
7.
Schulz V, Yan H, Lezon-Geyda K, An X, Hale J, Hillyer C, et al.
Cell Rep
. 2019 Sep;
28(11):2996-3009.e7.
PMID: 31509757
Mammalian erythropoiesis yields a highly specialized cell type, the mature erythrocyte, evolved to meet the organismal needs of increased oxygen-carrying capacity. To better understand the regulation of erythropoiesis, we performed...
8.
Gallagher P, Maksimova Y, Lezon-Geyda K, Newburger P, Medeiros D, Hanson R, et al.
J Clin Invest
. 2019 May;
129(7):2878-2887.
PMID: 31038472
The etiology of severe hemolytic anemia in most patients with recessive hereditary spherocytosis (rHS) and the related disorder hereditary pyropoikilocytosis (HPP) is unknown. Whole exome sequencing of DNA from probands...
9.
Hu X, Liu Z, Chen X, Schulz V, Kumar A, Hartman A, et al.
Nat Commun
. 2019 Apr;
10(1):1695.
PMID: 30979898
Actin cytoskeleton is well-known for providing structural/mechanical support, but whether and how it regulates chromatin and cell fate reprogramming is far less clear. Here, we report that MKL1, the key...
10.
Rahman N, Schulz V, Wang L, Gallagher P, Denisenko O, Gualdrini F, et al.
Blood Adv
. 2018 Oct;
2(20):2691-2703.
PMID: 30337297
Serum response factor (SRF) is a ubiquitously expressed transcription factor that binds DNA at CArG (CC[A/T]GG) domains in association with myocardin-family proteins (eg, myocardin-related transcription factor A [MRTFA]) or the...