Vincent J Hilser
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Explore the profile of Vincent J Hilser including associated specialties, affiliations and a list of published articles.
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75
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2492
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Recent Articles
1.
Impact of local unfolding fluctuations on the evolution of regional sequence preferences in proteins
Voortman-Sheetz K, Wrabl J, Hilser V
Protein Sci
. 2025 Feb;
34(3):e70015.
PMID: 39969063
The number of distinct structural environments in the proteome (as observed in the Protein Data Bank) may belie an organizing framework, whereby evolution conserves the relative stability of different sequence...
2.
Hilser V, Wrabl J, Millard C, Schmitz A, Brantley S, Pearce M, et al.
Annu Rev Biophys
. 2025 Feb;
PMID: 39929551
The growing appreciation of native state conformational fluctuations mediating protein function calls for critical reevaluation of protein evolution and adaptation. If proteins are ensembles, does nature select solely for ground...
3.
Posey A, Ross K, Bagheri M, Lanum E, Khan M, Jennings C, et al.
Protein Sci
. 2023 Sep;
32(11):e4787.
PMID: 37743569
Dynamins are an essential superfamily of mechanoenzymes that remodel membranes and often contain a "variable domain" important for regulation. For the mitochondrial fission dynamin, dynamin-related protein 1, a regulatory role...
4.
Posey A, Bagheri M, Ross K, Lanum E, Khan M, Jennings C, et al.
bioRxiv
. 2023 Jul;
PMID: 37398258
Dynamins are an essential superfamily of mechanoenzymes that remodel membranes and often contain a "variable domain" (VD) important for regulation. For the mitochondrial fission dynamin, Drp1, a regulatory role for...
5.
Chin A, Wrabl J, Hilser V
Mol Biol Evol
. 2022 Jan;
39(3).
PMID: 35038744
Protein stability is a fundamental molecular property enabling organisms to adapt to their biological niches. How this is facilitated and whether there are kingdom specific or more general universal strategies...
6.
Chin A, Zheng Y, Hilser V
Protein Sci
. 2022 Jan;
31(4):822-834.
PMID: 34984754
Intrinsically disordered proteins (IDPs) effect biological function despite their sequence-encoded lack of preference for stable three-dimensional structure. Among their many functions, IDPs form membraneless cellular compartments through liquid-liquid phase separation...
7.
White J, Rives J, Tharp M, Wrabl J, Thompson E, Hilser V
Biochemistry
. 2021 May;
60(21):1647-1657.
PMID: 34009973
Tumor susceptibility gene 101 (TSG101) is involved in endosomal maturation and has been implicated in the transcriptional regulation of several steroid hormone receptors, although a detailed characterization of such regulation...
8.
Conserved allosteric ensembles in disordered proteins using TROSY/anti-TROSY R-filtered spectroscopy
Grasso E, Majumdar A, Wrabl J, Frueh D, Hilser V
Biophys J
. 2021 Apr;
120(12):2498-2510.
PMID: 33901472
Defining the role of intrinsic disorder in proteins in the myriad of biological processes with which it is involved represents a significant goal in modern biophysics. Toward this end, NMR...
9.
Asangani I, Blair I, Van Duyne G, Hilser V, Moiseenkova-Bell V, Plymate S, et al.
J Biol Chem
. 2021 Jan;
296:100240.
PMID: 33384381
Castration resistant prostate cancer (CRPC) continues to be androgen receptor (AR) driven. Inhibition of AR signaling in CRPC could be advanced using state-of-the-art biophysical and biochemical techniques. Structural characterization of...
10.
Cho M, Wrabl J, Taylor J, Hilser V
Proc Natl Acad Sci U S A
. 2020 Sep;
117(38):23606-23616.
PMID: 32900925
Phosphorylation sites are hyperabundant in the eukaryotic disordered proteome, suggesting that conformational fluctuations play a major role in determining to what extent a kinase interacts with a particular substrate. In...