James O Wrabl
Overview
Explore the profile of James O Wrabl including associated specialties, affiliations and a list of published articles.
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26
Citations
1053
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Recent Articles
1.
Impact of local unfolding fluctuations on the evolution of regional sequence preferences in proteins
Voortman-Sheetz K, Wrabl J, Hilser V
Protein Sci
. 2025 Feb;
34(3):e70015.
PMID: 39969063
The number of distinct structural environments in the proteome (as observed in the Protein Data Bank) may belie an organizing framework, whereby evolution conserves the relative stability of different sequence...
2.
Hilser V, Wrabl J, Millard C, Schmitz A, Brantley S, Pearce M, et al.
Annu Rev Biophys
. 2025 Feb;
PMID: 39929551
The growing appreciation of native state conformational fluctuations mediating protein function calls for critical reevaluation of protein evolution and adaptation. If proteins are ensembles, does nature select solely for ground...
3.
Sengupta S, Zhang J, Reed M, Yu J, Kim A, Boronina T, et al.
J Exp Med
. 2023 Apr;
220(7).
PMID: 37058141
Distinct CD4+ T cell epitopes have been associated with spontaneous control of HIV-1 replication, but analysis of antigen-dependent factors that influence epitope selection is lacking. To examine these factors, we...
4.
Chin A, Wrabl J, Hilser V
Mol Biol Evol
. 2022 Jan;
39(3).
PMID: 35038744
Protein stability is a fundamental molecular property enabling organisms to adapt to their biological niches. How this is facilitated and whether there are kingdom specific or more general universal strategies...
5.
White J, Rives J, Tharp M, Wrabl J, Thompson E, Hilser V
Biochemistry
. 2021 May;
60(21):1647-1657.
PMID: 34009973
Tumor susceptibility gene 101 (TSG101) is involved in endosomal maturation and has been implicated in the transcriptional regulation of several steroid hormone receptors, although a detailed characterization of such regulation...
6.
Conserved allosteric ensembles in disordered proteins using TROSY/anti-TROSY R-filtered spectroscopy
Grasso E, Majumdar A, Wrabl J, Frueh D, Hilser V
Biophys J
. 2021 Apr;
120(12):2498-2510.
PMID: 33901472
Defining the role of intrinsic disorder in proteins in the myriad of biological processes with which it is involved represents a significant goal in modern biophysics. Toward this end, NMR...
7.
Cho M, Wrabl J, Taylor J, Hilser V
Proc Natl Acad Sci U S A
. 2020 Sep;
117(38):23606-23616.
PMID: 32900925
Phosphorylation sites are hyperabundant in the eukaryotic disordered proteome, suggesting that conformational fluctuations play a major role in determining to what extent a kinase interacts with a particular substrate. In...
8.
Sowers M, Anderson A, Wrabl J, Yin Y
J Am Chem Soc
. 2019 Jun;
141(27):10821-10829.
PMID: 31251605
High fidelity human mitochondrial DNA polymerase (Pol γ) contains two active sites, a DNA polymerization site () and a 3'-5' exonuclease site () for proofreading. Although separated by 35 Å,...
9.
Hoffmann J, Wrabl J, Hilser V
Proteins
. 2018 Dec;
86(12):1313.
PMID: 30549116
No abstract available.
10.
Saavedra H, Wrabl J, Anderson J, Li J, Hilser V
Nature
. 2018 Jun;
558(7709):324-328.
PMID: 29875414
Adaptation of organisms to environmental niches is a hallmark of evolution. One prevalent example is that of thermal adaptation, in which two descendants evolve at different temperature extremes. Underlying the...