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Vincent J Hilser

Explore the profile of Vincent J Hilser including associated specialties, affiliations and a list of published articles. Areas
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Articles 75
Citations 2492
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Recent Articles
11.
Wodak S, Paci E, Dokholyan N, Berezovsky I, Horovitz A, Li J, et al.
Structure . 2019 Feb; 27(4):566-578. PMID: 30744993
Allosteric regulation plays an important role in many biological processes, such as signal transduction, transcriptional regulation, and metabolism. Allostery is rooted in the fundamental physical properties of macromolecular systems, but...
12.
Hoffmann J, Wrabl J, Hilser V
Proteins . 2018 Dec; 86(12):1313. PMID: 30549116
No abstract available.
13.
Li J, Hilser V
Methods Enzymol . 2018 Nov; 611:531-557. PMID: 30471699
Intrinsically disordered (ID) proteins have been shown to play a major role in signaling in a broad range of proteins, using a process known as allostery, wherein the protein can...
14.
Saavedra H, Wrabl J, Anderson J, Li J, Hilser V
Nature . 2018 Jun; 558(7709):324-328. PMID: 29875414
Adaptation of organisms to environmental niches is a hallmark of evolution. One prevalent example is that of thermal adaptation, in which two descendants evolve at different temperature extremes. Underlying the...
15.
White J, Li J, Grasso E, Wrabl J, Hilser V
Philos Trans R Soc Lond B Biol Sci . 2018 May; 373(1749). PMID: 29735729
Allostery is an important regulatory phenomenon enabling precise control of biological function. Initial understanding of allostery was gained from seminal work on conformational changes exhibited by structured proteins. Within the...
16.
Li J, White J, Saavedra H, Wrabl J, Motlagh H, Liu K, et al.
Elife . 2018 Feb; 7. PMID: 29431606
No abstract available.
17.
Li J, White J, Saavedra H, Wrabl J, Motlagh H, Liu K, et al.
Elife . 2017 Oct; 6. PMID: 29022880
Intrinsically disordered proteins (IDPs) present a functional paradox because they lack stable tertiary structure, but nonetheless play a central role in signaling, utilizing a process known as allostery. Historically, allostery...
18.
White J, Toptygin D, Cohen R, Murphy N, Hilser V
Biochemistry . 2017 Aug; 56(35):4646-4655. PMID: 28776372
The tumor susceptibility gene-101 coiled coil domain (TSG101cc) is an integral component of the endosomal maturation machinery and cytokinesis, and also interacts with several transcription factors. The TSG101cc has been...
19.
Motlagh H, Anderson J, Li J, Hilser V
Biophys Rev . 2017 May; 7(2):257-265. PMID: 28510173
Allostery is a biological regulation mechanism of significant importance in cell signaling, metabolism, and disease. Although the ensemble basis of allostery has been known for years, only recently has emphasis...
20.
Chin A, Hilser V
Structure . 2017 Apr; 25(4):573-575. PMID: 28380337
The number of examples of functional post-translational modulation of disordered proteins rapidly grows. In a recent issue of Structure, Jie et al. (2017) show that phosphorylation of dynein intermediate chain...