Vincent C Chen
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Explore the profile of Vincent C Chen including associated specialties, affiliations and a list of published articles.
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29
Citations
721
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Recent Articles
1.
Broome J, Nguyen N, Baumung C, Chen V, Bushnell E
Biochemistry
. 2024 Sep;
63(20):2682-2691.
PMID: 39318042
Human isocitrate dehydrogenase 1 (IDH1) is an enzyme that is found in humans that plays a critical role in aerobic metabolism. As a part of the citric acid cycle, IDH1...
2.
Teraiya M, Krokhin O, Chen V, Perreault H
J Proteome Res
. 2023 Dec;
23(1):465-482.
PMID: 38147655
Temozolomide (TMZ) is the first line of chemotherapy to treat primary brain tumors of the type glioblastoma multiforme (GBM). TMZ resistance (TMZR) is one of the main barriers to successful...
3.
Teraiya M, Perreault H, Chen V
Front Oncol
. 2023 May;
13:1166207.
PMID: 37182181
Glioblastoma multiforme (GBM) is a primary type of lethal brain tumor. Over the last two decades, temozolomide (TMZ) has remained the primary chemotherapy for GBM. However, TMZ resistance in GBM...
4.
Feser R, Opperman R, Nault B, Maiti S, Chen V, Majumder M
Heliyon
. 2023 May;
9(4):e15421.
PMID: 37128318
MicroRNA (miRNA/miR) 526 b- and miR655-overexpressed tumor cell-free secretions regulate the breast cancer tumor microenvironment (TME) by promoting tumor-associated angiogenesis, oxidative stress, and hypoxic responses. Additionally, premature miRNA (pri-miR526b and...
5.
Helwer R, Chen V
Methods Mol Biol
. 2022 May;
2456:173-183.
PMID: 35612742
A fundamental goal of systems biology is to seek a better understanding of the cell's molecular mechanisms. Experimentalists most frequently rely upon reductionist methods to isolate and analyze discrete signaling...
6.
Poole A, Sitko C, Le C, Naus C, Hill B, Bushnell E, et al.
J Enzyme Inhib Med Chem
. 2020 Mar;
35(1):672-681.
PMID: 32156166
Glioblastoma multiforme (GBM) is the deadliest and the most common primary malignant brain tumour. The median survival for patients with GBM is around one year due to the nature of...
7.
Aftab Q, Mesnil M, Ojefua E, Poole A, Noordenbos J, Strale P, et al.
Front Neurosci
. 2019 Apr;
13:143.
PMID: 30941001
Extracellular matrix (ECM) remodeling, degradation and glioma cell motility are critical aspects of glioblastoma multiforme (GBM). Despite being a rich source of potential biomarkers and targets for therapeutic advance, the...
8.
Le Vasseur M, Chen V, Huang K, Vogl W, Naus C
Cancers (Basel)
. 2019 Mar;
11(3).
PMID: 30862038
Endomembrane specialization allows functional compartmentalization but imposes physical constraints to information flow within the cell. However, the evolution of an endomembrane system was associated with the emergence of contact sites...
9.
Abilez O, Tzatzalos E, Yang H, Zhao M, Jung G, Zollner A, et al.
Stem Cells
. 2017 Nov;
36(2):265-277.
PMID: 29086457
The ability to differentiate human pluripotent stem cells (hPSCs) into cardiomyocytes (CMs) makes them an attractive source for repairing injured myocardium, disease modeling, and drug testing. Although current differentiation protocols...
10.
Cheng B, Chen P, Yang Y, Lee C, Huang K, Chen V
Medicine (Baltimore)
. 2016 Sep;
95(36):e4655.
PMID: 27603358
This study was conducted to investigate the effects of depression and antidepressant medications on hip fracture. The database of the Taiwan National Health Insurance with medical records of more than...