Larry A Couture
Overview
Explore the profile of Larry A Couture including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
1105
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Recent Articles
1.
Abilez O, Tzatzalos E, Yang H, Zhao M, Jung G, Zollner A, et al.
Stem Cells
. 2017 Nov;
36(2):265-277.
PMID: 29086457
The ability to differentiate human pluripotent stem cells (hPSCs) into cardiomyocytes (CMs) makes them an attractive source for repairing injured myocardium, disease modeling, and drug testing. Although current differentiation protocols...
2.
Tiburcy M, Hudson J, Balfanz P, Schlick S, Meyer T, Chang Liao M, et al.
Circulation
. 2017 Feb;
135(19):1832-1847.
PMID: 28167635
Background: Advancing structural and functional maturation of stem cell-derived cardiomyocytes remains a key challenge for applications in disease modeling, drug screening, and heart repair. Here, we sought to advance cardiomyocyte...
3.
Tompkins J, Jung M, Chen C, Lin Z, Ye J, Godatha S, et al.
EBioMedicine
. 2016 Mar;
4:74-85.
PMID: 26981572
The directed differentiation of human cardiomyocytes (CMs) from pluripotent cells provides an invaluable model for understanding mechanisms of cell fate determination and offers considerable promise in cardiac regenerative medicine. Here,...
4.
Chen V, Ye J, Shukla P, Hua G, Chen D, Lin Z, et al.
Stem Cell Res
. 2015 Aug;
15(2):365-75.
PMID: 26318718
To meet the need of a large quantity of hPSC-derived cardiomyocytes (CM) for pre-clinical and clinical studies, a robust and scalable differentiation system for CM production is essential. With a...
5.
Human Engineered Heart Muscles Engraft and Survive Long Term in a Rodent Myocardial Infarction Model
Riegler J, Tiburcy M, Ebert A, Tzatzalos E, Raaz U, Abilez O, et al.
Circ Res
. 2015 Aug;
117(8):720-30.
PMID: 26291556
Rationale: Tissue engineering approaches may improve survival and functional benefits from human embryonic stem cell-derived cardiomyocyte transplantation, thereby potentially preventing dilative remodeling and progression to heart failure. Objective: Assessment of...
6.
Couture L, Carpenter M
Stem Cells Transl Med
. 2015 Aug;
4(10):1097-100.
PMID: 26285658
Unlabelled: Several human embryonic stem cell (hESC)-derived cell therapeutics have entered clinical testing and more are in various stages of preclinical development. The U.S. Food and Drug Administration (FDA) regulates...
7.
Neofytou E, OBrien C, Couture L, Wu J
J Clin Invest
. 2015 Jul;
125(7):2551-7.
PMID: 26132109
Human pluripotent stem cells are known to have the capacity to renew indefinitely, being intrinsically able to differentiate into many different cell types. These characteristics have generated tremendous enthusiasm about...
8.
Bajgain P, Mucharla R, Wilson J, Welch D, Anurathapan U, Liang B, et al.
Mol Ther Methods Clin Dev
. 2015 May;
1:14015.
PMID: 26015959
Broader implementation of cell-based therapies has been hindered by the logistics associated with the expansion of clinically relevant cell numbers ex vivo. To overcome this limitation, Wilson Wolf Manufacturing developed...
9.
Chen V, Couture L
Methods Mol Biol
. 2014 Dec;
1283:13-21.
PMID: 25537838
Suspension cell culture systems with superior scalability, controllability, and monitoring options are an attractive alternative to static adherent culture methods for expansion and production of human pluripotent stem cells (hPSCs),...
10.
Lindblad R, Ibenana L, Wagner J, McKenna Jr D, Hei D, Hematti P, et al.
Transfusion
. 2014 Oct;
55(3):674-9.
PMID: 25315143
No abstract available.