Viktor Todorovic
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Explore the profile of Viktor Todorovic including associated specialties, affiliations and a list of published articles.
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20
Citations
515
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Recent Articles
1.
Su Z, Slivka P, Paulsboe S, Chu K, Wetter J, Namovic M, et al.
J Dermatol
. 2023 Jul;
50(10):1321-1329.
PMID: 37455419
Phospholipase D2 (PLD2), a major isoform of the PLD family, has been reported to regulate inflammatory responses. Thus far, the relevance of PLD2 in psoriasis, an inflammatory skin disease, has...
2.
Todorovic V, McDonald H, Hoover P, Wetter J, Marinopoulos A, Woody C, et al.
Exp Dermatol
. 2022 Feb;
31(7):1036-1047.
PMID: 35213752
Psoriasis vulgaris is an inflammatory skin disease that affects 2%-3% of the population worldwide. One of the major challenges in discovering novel therapies is the poor translatability of animal models...
3.
Dunstan R, Salte K, Todorovic V, Lowe M, Wetter J, Harms P, et al.
Exp Dermatol
. 2020 Dec;
30(6):820-830.
PMID: 33377546
Since first recognized in 1839, the pathogenesis of acne inversa (AI) has undergone repeated revisions. Although there is agreement that AI involves occlusion of hair follicles with subsequent inflammation and...
4.
Zhou L, Todorovic V
Adv Exp Med Biol
. 2020 Feb;
21:191-210.
PMID: 32026417
The IL-36 family belongs to a larger IL-1 superfamily and consists of three agonists (IL-36α/β/γ), one antagonist (IL-36Ra), one cognate receptor (IL-36R) and one accessory protein (IL-1RAcP). The receptor activation...
5.
Todorovic V, Su Z, Putman C, Kakavas S, Salte K, McDonald H, et al.
Sci Rep
. 2019 Jun;
9(1):9089.
PMID: 31235749
IL-36 cytokines are pro-inflammatory members of the IL-1 family that are upregulated in inflammatory disorders. Specifically, IL-36γ is highly expressed in active psoriatic lesions and can drive pro-inflammatory processes in...
6.
Su Z, Paulsboe S, Wetter J, Salte K, Kannan A, Mathew S, et al.
Exp Dermatol
. 2018 Nov;
28(2):113-120.
PMID: 30417427
Psoriasis vulgaris (PV) results from activation of IL-23/Th17 immune pathway and is further amplified by cytokines/chemokines from skin cells. Among skin-derived pro-inflammatory cytokines, IL-36 family members are highly upregulated in...
7.
Zhou L, Todorovic V, Kakavas S, Sielaff B, Medina L, Wang L, et al.
J Biol Chem
. 2017 Nov;
293(2):403-411.
PMID: 29180446
IL-36 cytokines signal through the IL-36 receptor (IL-36R) and a shared subunit, IL-1RAcP (IL-1 receptor accessory protein). The activation mechanism for the IL-36 pathway is proposed to be similar to...
8.
Stockmann H, Todorovic V, Richardson P, Marin V, Scott V, Gerstein C, et al.
J Am Chem Soc
. 2017 Oct;
139(46):16822-16829.
PMID: 29068676
Ligand-binding assays are the linchpin of drug discovery and medicinal chemistry. Cell-surface receptors and their ligands have traditionally been characterized by radioligand-binding assays, which have low temporal and spatial resolution...
9.
Todorovic V, Koetsier J, Godsel L, Green K
Mol Biol Cell
. 2014 Sep;
25(23):3749-64.
PMID: 25208567
The pathways driving desmosome and adherens junction assembly are temporally and spatially coordinated, but how they are functionally coupled is poorly understood. Here we show that the Armadillo protein plakophilin...
10.
Koetsier J, Amargo E, Todorovic V, Green K, Godsel L
J Invest Dermatol
. 2013 Jul;
134(1):112-122.
PMID: 23884246
Plakophilin 2 (PKP2), a desmosome component, modulates the activity and localization of the small GTPase RhoA at sites of cell-cell contact. PKP2 regulates cortical actin rearrangement during junction formation, and...