Victor S Goldmacher
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Explore the profile of Victor S Goldmacher including associated specialties, affiliations and a list of published articles.
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30
Citations
1549
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Recent Articles
1.
Goldmacher V, Gershteyn I, Kovtun Y
Antib Ther
. 2025 Mar;
7(4):351-360.
PMID: 40061208
Bispecific apoptosis triggers (BATs) are innovative bispecific antibodies designed to simultaneously target both a tumor-associated antigen and a cancer cell's death receptor, thereby directly activating the extrinsic apoptotic pathway to...
2.
Kovtun Y, Jones G, Adams S, Harvey L, Audette C, Wilhelm A, et al.
Blood Adv
. 2018 Apr;
2(8):848-858.
PMID: 29661755
The outlook for patients with refractory/relapsed acute myeloid leukemia (AML) remains poor, with conventional chemotherapeutic treatments often associated with unacceptable toxicities, including severe infections due to profound myelosuppression. Thus there...
3.
Ab O, Whiteman K, Bartle L, Sun X, Singh R, Tavares D, et al.
Mol Cancer Ther
. 2015 Apr;
14(7):1605-13.
PMID: 25904506
A majority of ovarian and non-small cell lung adenocarcinoma cancers overexpress folate receptor α (FRα). Here, we report the development of an anti-FRα antibody-drug conjugate (ADC), consisting of a FRα-binding...
4.
Goldmacher V, Audette C, Guan Y, Sidhom E, Shah J, Whiteman K, et al.
PLoS One
. 2015 Feb;
10(2):e0117523.
PMID: 25671541
The microtubule-targeting maytansinoids accumulate in cells and induce mitotic arrest at 250- to 1000-fold lower concentrations than those required for their association with tubulin or microtubules. To identify the mechanisms...
5.
Goldmacher V, Amphlett G, Wang L, Lazar A
Mol Pharm
. 2015 Jan;
12(6):1738-44.
PMID: 25635630
The maytansinoid antibody-drug conjugates (ADCs) in clinical development for cancer therapy each contain a derivative of the microtubule-targeting agent, maytansine, covalently attached to the antibody via an engineered linker. A...
6.
Deckert J, Wetzel M, Bartle L, Skaletskaya A, Goldmacher V, Vallee F, et al.
Clin Cancer Res
. 2014 Jul;
20(17):4574-83.
PMID: 24987056
Purpose: The CD38 cell surface antigen is expressed in diverse hematologic malignancies including multiple myeloma, B-cell non-Hodgkin lymphoma (NHL), B-cell chronic lymphocytic leukemia, B-cell acute lymphoblastic leukemia (ALL), and T-cell...
7.
Pode-Shakked N, Shukrun R, Mark-Danieli M, Tsvetkov P, Bahar S, Pri-Chen S, et al.
EMBO Mol Med
. 2012 Dec;
5(1):18-37.
PMID: 23239665
There are considerable differences in tumour biology between adult and paediatric cancers. The existence of cancer initiating cells/cancer stem cells (CIC/CSC) in paediatric solid tumours is currently unclear. Here, we...
8.
Goldmacher V, Kovtun Y
Ther Deliv
. 2012 Jul;
2(3):397-416.
PMID: 22834009
One approach to improving activity of anticancer drugs is to conjugate them to antibodies that recognize tumor-associated, cell-surface antigens. The antibody-drug conjugate concept evolved following major advances, first, in the...
9.
Zhao R, Erickson H, Leece B, Reid E, Goldmacher V, Lambert J, et al.
J Med Chem
. 2011 Dec;
55(2):766-82.
PMID: 22148292
The synthesis and biological evaluation of phosphate prodrugs of analogues of 1 (CC-1065) and their conjugates with antibodies are described. The phosphate group on the 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) portion of the...
10.
Zhao R, Wilhelm S, Audette C, Jones G, Leece B, Lazar A, et al.
J Med Chem
. 2011 Apr;
54(10):3606-23.
PMID: 21517041
The synthesis and biological evaluation of hydrophilic heterobifunctional cross-linkers for conjugation of antibodies with highly cytotoxic agents are described. These linkers contain either a negatively charged sulfonate group or a...