Victor H Villar
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Explore the profile of Victor H Villar including associated specialties, affiliations and a list of published articles.
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14
Citations
3130
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Recent Articles
1.
Ackermann T, Shokry E, Deshmukh R, Anand J, Galbraith L, Mitchell L, et al.
EMBO Mol Med
. 2024 Oct;
16(11):2749-2774.
PMID: 39433871
The limited availability of therapeutic options for patients with triple-negative breast cancer (TNBC) contributes to the high rate of metastatic recurrence and poor prognosis. Ferroptosis is a type of cell...
2.
Santibanez J, Villar V, Echeverria C
Pharmaceutics
. 2023 May;
15(5).
PMID: 37242785
Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020 and ranking as the second-leading cause of death in economically developed countries [...].
3.
Villar V, Suboticki T, dikic D, Mitrovic-Ajtic O, Simon F, Santibanez J
Adv Exp Med Biol
. 2023 Apr;
1408:309-328.
PMID: 37093435
Transforming growth factor-beta1 (TGF-β) regulates a plethora of cell-intrinsic processes that modulate tumor progression in a context-dependent manner. Thus, although TGF-β acts as a tumor suppressor in the early stages...
4.
Villar V, Allega M, Deshmukh R, Ackermann T, Nakasone M, Vande Voorde J, et al.
Nat Chem Biol
. 2022 Oct;
19(3):292-300.
PMID: 36280791
Glutamine synthetase (GS) activity is conserved from prokaryotes to humans, where the ATP-dependent production of glutamine from glutamate and ammonia is essential for neurotransmission and ammonia detoxification. Here, we show...
5.
Taurino G, Deshmukh R, Villar V, Chiu M, Shaw R, Hedley A, et al.
Mol Metab
. 2022 Jun;
63:101532.
PMID: 35752287
Bone marrow mesenchymal stromal cells (MSCs) have immunomodulatory and regenerative potential. However, culture conditions govern their metabolic processes and therapeutic efficacy. Here we show that culturing donor-derived MSCs in Plasmax™,...
6.
Mojsilovic S, Mojsilovic S, Villar V, Santibanez J
Anal Cell Pathol (Amst)
. 2021 Sep;
2021:5523055.
PMID: 34476174
Besides transformed cells, the tumors are composed of various cell types that contribute to undesirable tumor progression. Tumor-associated macrophages (TAMs) are the most abundant innate immune cells in the tumor...
7.
Bodineau C, Tome M, Courtois S, Costa A, Sciacovelli M, Rousseau B, et al.
Nat Commun
. 2021 Aug;
12(1):4814.
PMID: 34376668
Glutamoptosis is the induction of apoptotic cell death as a consequence of the aberrant activation of glutaminolysis and mTORC1 signaling during nutritional imbalance in proliferating cells. The role of the...
8.
Hulme H, Meikle L, Strittmatter N, van der Hooft J, Swales J, Bragg R, et al.
Sci Adv
. 2020 Mar;
6(11):eaax6328.
PMID: 32195337
Alterations to the gut microbiome are associated with various neurological diseases, yet evidence of causality and identity of microbiome-derived compounds that mediate gut-brain axis interaction remain elusive. Here, we identify...
9.
Alemany R, Moura D, Redondo A, Martinez-Trufero J, Calabuig S, Saus C, et al.
Clin Cancer Res
. 2018 Jul;
24(21):5239-5249.
PMID: 30037815
Nilotinib plus doxorubicin showed to be synergistic regarding apoptosis in several sarcoma cell lines. A phase I/II trial was thus designed to explore the feasibility of nilotinib as coadjuvant of...
10.
Villar V, Nguyen T, Teres S, Bodineau C, Duran R
Mol Cell Oncol
. 2017 Jun;
4(3):e1297284.
PMID: 28616576
A master promoter of cell growth, mammalian target of rapamycin (mTOR) is upregulated in a large percentage of cancer cells. Still, targeting mTOR using rapamycin has a limited outcome in...