Victor DeFilippis
Overview
Explore the profile of Victor DeFilippis including associated specialties, affiliations and a list of published articles.
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Articles
24
Citations
730
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Recent Articles
1.
Garzan A, Ahmed S, Haese N, Sulgey G, Medica S, Smith J, et al.
J Med Chem
. 2024 Dec;
67(23):20858-20878.
PMID: 39621435
2-(Methylthio)--(4-(naphthalen-2-yl)thiazol-2-yl)nicotinamide was identified as an inhibitor against Chikungunya virus (CHIKV) with good antiviral activity [EC = 0.6 μM; EC = 0.93 μM and viral titer reduction (VTR) of 6.9 logs...
2.
Weber W, Labriola C, Kreklywich C, Ray K, Haese N, Andoh T, et al.
PLoS Negl Trop Dis
. 2023 Nov;
17(11):e0011742.
PMID: 37983245
Mayaro virus (MAYV) is a mosquito-transmitted alphavirus that causes debilitating and persistent arthritogenic disease. While MAYV was previously reported to infect non-human primates (NHP), characterization of MAYV pathogenesis is currently...
3.
Connors J, Taramangalam B, Cusimano G, Bell M, Matt S, Runner K, et al.
Geroscience
. 2022 Jul;
44(5):2555-2572.
PMID: 35849213
The progressive impairment of immunity to pathogens and vaccines with aging is a significant public health problem as the world population shifts to an increased percentage of older adults (> ...
4.
Foss M, Stevens S, Jin H, Allen E, Nelson D, DeFilippis V, et al.
ACS Chem Biol
. 2022 Apr;
17(5):1073-1081.
PMID: 35471821
We sought to develop a small-molecule activator of interferon regulatory factor 3 (IRF3), an essential innate immune transcription factor, which could potentially be used therapeutically in multiple disease settings. Using...
5.
Haese N, May N, Taft-Benz S, Moukha-Chafiq O, Madadi N, Zhang S, et al.
Antimicrob Agents Chemother
. 2021 Jun;
65(9):e0024421.
PMID: 34152810
Venezuelan equine encephalitis virus (VEEV) is a reemerging alphavirus that can cause encephalitis resulting in severe human morbidity and mortality. Using a high-throughput cell-based screen, we identified a quinolinone compound...
6.
Ahmed S, Haese N, Cowan J, Pathak V, Moukha-Chafiq O, Smith V, et al.
J Med Chem
. 2021 Apr;
64(8):4762-4786.
PMID: 33835811
A benzo[6]annulene, 4-(-butyl)--(3-methoxy-5,6,7,8-tetrahydronaphthalen-2-yl) benzamide (), was identified as an inhibitor against Chikungunya virus (CHIKV) with antiviral activity EC = 1.45 μM and viral titer reduction (VTR) of 2.5 log at...
7.
Powers J, Haese N, Denton M, Ando T, Kreklywich C, Bonin K, et al.
PLoS Negl Trop Dis
. 2021 Apr;
15(4):e0009308.
PMID: 33793555
Mayaro virus (MAYV) is an alphavirus endemic to South and Central America associated with sporadic outbreaks in humans. MAYV infection causes severe joint and muscle pain that can persist for...
8.
Broeckel R, Haese N, Ando T, Dmitriev I, Kreklywich C, Powers J, et al.
Front Immunol
. 2019 Nov;
10:2563.
PMID: 31736977
Chikungunya virus (CHIKV) infections can cause severe and debilitating joint and muscular pain that can be long lasting. Current CHIKV vaccines under development rely on the generation of neutralizing antibodies...
9.
Nguyen T, Haese N, Madadi N, Sarkar S, Bonin K, Streblow C, et al.
ACS Infect Dis
. 2019 Jul;
5(12):2014-2028.
PMID: 31257853
Alphaviruses are arthropod-transmitted members of the Togaviridae family that can cause severe disease in humans, including debilitating arthralgia and severe neurological complications. Currently, there are no approved vaccines or antiviral...
10.
Hirsch A, Roberts V, Grigsby P, Haese N, Schabel M, Wang X, et al.
Nat Commun
. 2018 Jan;
9(1):263.
PMID: 29343712
Zika virus (ZIKV) infection during pregnancy leads to an increased risk of fetal growth restriction and fetal central nervous system malformations, which are outcomes broadly referred to as the Congenital...