Thomas E Morrison
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Explore the profile of Thomas E Morrison including associated specialties, affiliations and a list of published articles.
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115
Citations
3869
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Recent Articles
1.
Ghoshal A, Tse E, Hossain M, Asressu K, Merten E, Sears J, et al.
Sci Rep
. 2025 Mar;
15(1):7264.
PMID: 40025188
Chikungunya is a mosquito-borne viral disease that causes fever and severe joint pain for which there is no direct acting drug treatments. Vinyl sulfone SGC-NSP2PRO-1 (3) was identified as a...
2.
Yin P, Sobolik E, May N, Wang S, Fayed A, Vyshenska D, et al.
PLoS Pathog
. 2025 Jan;
21(1):e1012859.
PMID: 39804924
Chikungunya virus (CHIKV) is an arthritogenic alphavirus that has re-emerged to cause large outbreaks of human infections worldwide. There are currently no approved antivirals for treatment of CHIKV infection. Recently,...
3.
Martin C, Wan J, Yin P, Morrison T, Messer W, Rivera-Amill V, et al.
mBio
. 2024 Dec;
16(2):e0198624.
PMID: 39699169
The alphavirus chikungunya virus (CHIKV) is a serious human pathogen that can cause large-scale epidemics characterized by fever and joint pain and often resulting in chronic arthritis. Infection by alphaviruses...
4.
Stumpf M, Brunetti T, Davenport B, McCarthy M, Morrison T
bioRxiv
. 2024 Dec;
PMID: 39677653
As outbreaks of chikungunya virus (CHIKV), a mosquito-borne alphavirus, continue to present public health challenges, additional research is needed to generate protective and safe vaccines and effective therapeutics. Prior research...
5.
Ander S, Davenport B, Evans A, Morrison T
Methods Mol Biol
. 2024 Dec;
2893:285-298.
PMID: 39671045
During viral infection, phagocytic cells participate in numerous immunological processes. A common approach to elucidate the specific contributions of phagocytic cells is through direct comparison of viral pathogenesis of phagocyte-depleted...
6.
Garzan A, Ahmed S, Haese N, Sulgey G, Medica S, Smith J, et al.
J Med Chem
. 2024 Dec;
67(23):20858-20878.
PMID: 39621435
2-(Methylthio)--(4-(naphthalen-2-yl)thiazol-2-yl)nicotinamide was identified as an inhibitor against Chikungunya virus (CHIKV) with good antiviral activity [EC = 0.6 μM; EC = 0.93 μM and viral titer reduction (VTR) of 6.9 logs...
7.
Ghoshal A, Tse E, Hossain M, Asressu K, Merten E, Sears J, et al.
Res Sq
. 2024 Nov;
PMID: 39606462
RA-0003022 () was identified as a high-quality covalent chemical probe for nsP2 cysteine protease (nsP2pro). Isoxazole covalently captured the active site C478 and inactivated the enzyme with a / ratio...
8.
Catala A, Davenport B, Morrison T, Catalano C
Vaccines (Basel)
. 2024 Nov;
12(11).
PMID: 39591104
The recent SARS-CoV-2 (COVID-19) pandemic exemplifies how newly emerging and reemerging viruses can quickly overwhelm and cripple global infrastructures. Coupled with synergistic factors such as increasing population densities, the constant...
9.
Bullock C, Wang L, Ware B, Wagoner N, Ohara R, Liu T, et al.
mBio
. 2024 Nov;
15(12):e0293024.
PMID: 39535221
Ross River virus (RRV) and other alphaviruses cause chronic musculoskeletal syndromes that are associated with viral persistence, which suggests deficits in immune clearance mechanisms, including CD8 T-cell responses. Here, we...
10.
Hu P, Xiao H, Alba M, Atkins H, Gou S, Hu Y, et al.
Kidney Int
. 2024 Aug;
106(5):870-886.
PMID: 39216658
Anti-neutrophil cytoplasmic autoantibody (ANCA) vasculitis has diverse patterns of injury including microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA), and eosinophilic granulomatosis with polyangiitis (EGPA). Necrotizing and crescentic glomerulonephritis (NCGN) occurs...