Venkatesh V Nemmara
Overview
Explore the profile of Venkatesh V Nemmara including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
477
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0
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Recent Articles
1.
Elbezanti W, Al-Odat O, Chitren R, Singh J, Srivastava S, Gowda K, et al.
Front Pharmacol
. 2022 Sep;
13:894535.
PMID: 36160379
Despite recent improvements in multiple myeloma (MM) treatment, MM remains an incurable disease and most patients experience a relapse. The major reason for myeloma recurrence is the persistent stem cell-like...
2.
Binder V, Chruscicka-Smaga B, Bergum B, Jaisson S, Gillery P, Sivertsen J, et al.
J Am Soc Nephrol
. 2022 Aug;
33(10):1841-1856.
PMID: 36038265
Background: Bleeding diatheses, common among patients with ESKD, can lead to serious complications, particularly during invasive procedures. Chronic urea overload significantly increases cyanate concentrations in patients with ESKD, leading to...
3.
Tilvawala R, Nemmara V, Reyes A, Sorvillo N, Salinger A, Cherpokova D, et al.
Cell Chem Biol
. 2021 Aug;
28(12):1728-1739.e5.
PMID: 34352225
Aberrant protein citrullination is associated with many pathologies; however, the specific effects of this modification remain unknown. We have previously demonstrated that serine protease inhibitors (SERPINs) are highly citrullinated in...
4.
Young C, Snow B, DeVore S, Mohandass A, Nemmara V, Thompson P, et al.
Reproduction
. 2021 May;
162(2):117-127.
PMID: 34034233
Peptidylarginine deiminases (PAD) enzymes were initially characterized in uteri, but since then little research has examined their function in this tissue. PADs post-translationally convert arginine residues in target proteins to...
5.
Tulluri V, Nemmara V
Onco Targets Ther
. 2021 Feb;
14:667-682.
PMID: 33531815
Polyamines are multivalent organic cations essential for many cellular functions, including cell growth, differentiation, and proliferation. However, elevated polyamine levels are associated with a slew of pathological conditions, including multiple...
6.
Humphries F, Shmuel-Galia L, Ketelut-Carneiro N, Li S, Wang B, Nemmara V, et al.
Science
. 2020 Aug;
369(6511):1633-1637.
PMID: 32820063
Activated macrophages undergo a metabolic switch to aerobic glycolysis, accumulating Krebs' cycle intermediates that alter transcription of immune response genes. We extended these observations by defining fumarate as an inhibitor...
7.
Li G, Young C, Snow B, Christensen A, Demoruelle M, Nemmara V, et al.
Int J Mol Sci
. 2020 Apr;
21(7).
PMID: 32290104
Citrullination is a post-translational modification (PTM) in which positively charged peptidyl-arginine is converted into neutral peptidyl-citrulline by peptidylarginine deiminase (PAD or PADI) enzymes. The full protein citrullinome in many tissues...
8.
Loring H, Icso J, Nemmara V, Thompson P
Biochemistry
. 2020 Feb;
59(8):933-942.
PMID: 32049506
Sterile alpha and toll/interleukin receptor (TIR) motif-containing protein 1 (SARM1) plays a pivotal role in triggering the neurodegenerative processes that underlie peripheral neuropathies, traumatic brain injury, and neurodegenerative diseases. Importantly,...
9.
Mukherjee K, Huddleston J, Narindoshvili T, Nemmara V, Raushel F
Biochemistry
. 2019 Feb;
58(10):1388-1399.
PMID: 30742415
A combination of bioinformatics, steady-state kinetics, and NMR spectroscopy has revealed the catalytic functions of YcjQ, YcjS, and YcjR from the ycj gene cluster in Escherichia coli K-12. YcjS was...
10.
Nemmara V, Xiang D, Fedorov A, Fedorov E, Bonanno J, Almo S, et al.
Biochemistry
. 2018 Oct;
57(43):6219-6227.
PMID: 30277746
The phosphotriesterase homology protein (PHP) from Escherichia coli is a member of a family of proteins that is related to phosphotriestrase (PTE), a bacterial enzyme from cog1735 with unusual substrate...