Vedanta Mehta
Overview
Explore the profile of Vedanta Mehta including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
386
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Recent Articles
1.
Aitken C, Mehta V, Schwartz M, Tzima E
Nat Cardiovasc Res
. 2024 Aug;
2(6):517-529.
PMID: 39195881
Fluid shear stress plays a key role in sculpting blood vessels during development, in adult vascular homeostasis and in vascular pathologies. During evolution, endothelial cells evolved several mechanosensors that convert...
2.
X S, Aitken C, Mehta V, Tardajos-Ayllon B, Serbanovic-Canic J, Zhu J, et al.
J Cell Sci
. 2024 Aug;
137(17).
PMID: 39143856
Fluid shear stress (FSS) from blood flow, sensed by the vascular endothelial cells (ECs) that line all blood vessels, regulates vascular development during embryogenesis, controls adult vascular physiology and determines...
3.
Mehta V, Pang K, Rozbesky D, Nather K, Keen A, Lachowski D, et al.
Nature
. 2022 May;
605(7910):E6.
PMID: 35504972
No abstract available.
4.
Mehta V, Mahmoud M
Methods Mol Biol
. 2022 Apr;
2475:229-238.
PMID: 35451762
The ex vivo aortic ring assay is one of the most widely used protocols to study sprouting angiogenesis. It is a highly adaptable method that can be utilized to investigate...
5.
Keen A, Payne L, Mehta V, Rice A, Simpson L, Pang K, et al.
J Cell Biol
. 2022 Jan;
221(2).
PMID: 35024764
The repertoire of extratranslational functions of components of the protein synthesis apparatus is expanding to include control of key cell signaling networks. However, very little is known about noncanonical functions...
6.
Mehta V, Pang K, Givens C, Chen Z, Huang J, Sweet D, et al.
Sci Adv
. 2021 Jul;
7(28).
PMID: 34244146
The response of endothelial cells to mechanical forces is a critical determinant of vascular health. Vascular pathologies, such as atherosclerosis, characterized by abnormal mechanical forces are frequently accompanied by endothelial-to-mesenchymal...
7.
Rossi C, Lees M, Mehta V, Heikura T, Martin J, Zachary I, et al.
Hum Gene Ther
. 2020 Sep;
31(21-22):1190-1202.
PMID: 32988220
Severe fetal growth restriction (FGR) affects 1:500 pregnancies, is untreatable and causes serious neonatal morbidity and death. Reduced uterine blood flow (UBF) and lack of bioavailable VEGF due to placental...
8.
Mehta V, Pang K, Rozbesky D, Nather K, Keen A, Lachowski D, et al.
Nature
. 2020 Feb;
578(7794):290-295.
PMID: 32025034
Shear stress on arteries produced by blood flow is important for vascular development and homeostasis but can also initiate atherosclerosis. Endothelial cells that line the vasculature use molecular mechanosensors to...
9.
Douglas G, Mehta V, Al Haj Zen A, Akoumianakis I, Goel A, Rashbrook V, et al.
Cardiovasc Res
. 2019 Oct;
116(11):1863-1874.
PMID: 31584065
Aims: Genome-wide association studies (GWAS) have consistently identified an association between coronary artery disease (CAD) and a locus on chromosome 10 containing a single gene, JCAD (formerly KIAA1462). However, little...
10.
Mahmoud M, Evans I, Mehta V, Pellet-Many C, Paliashvili K, Zachary I
Am J Physiol Cell Physiol
. 2019 Jan;
316(3):C424-C433.
PMID: 30649916
Neuropilin 1 (NRP1) is important for neuronal and cardiovascular development due to its role in conveying class 3 semaphorin and vascular endothelial growth factor signaling, respectively. NRP1 is expressed in...