Mechanisms of Endothelial Flow Sensing

Overview

Journal Nat Cardiovasc Res

Publisher Springer Nature

Specialty Cardiology & Vascular Diseases

Date 2024 Aug 28

PMID 39195881

Authors

Claire Aitken

Vedanta Mehta

Martin A Schwartz

Ellie Tzima

Affiliations

Soon will be listed here.

Abstract

Fluid shear stress plays a key role in sculpting blood vessels during development, in adult vascular homeostasis and in vascular pathologies. During evolution, endothelial cells evolved several mechanosensors that convert physical forces into biochemical signals, a process termed mechanotransduction. This Review discusses our understanding of endothelial flow sensing and suggests important questions for future investigation.

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