Vedanta Mehta
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Explore the profile of Vedanta Mehta including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
386
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Recent Articles
11.
Bubb K, Aubdool A, Moyes A, Lewis S, Drayton J, Tang O, et al.
Circulation
. 2018 Dec;
139(13):1612-1628.
PMID: 30586761
Background: Angiogenesis and vascular remodeling are complementary, innate responses to ischemic cardiovascular events, including peripheral artery disease and myocardial infarction, which restore tissue blood supply and oxygenation; the endothelium plays...
12.
Mehta V, Fields L, Evans I, Yamaji M, Pellet-Many C, Jones T, et al.
Arterioscler Thromb Vasc Biol
. 2018 Jun;
38(8):1845-1858.
PMID: 29880492
Objective- NRP1(neuropilin-1) acts as a coreceptor for VEGF (vascular endothelial growth factor) with an essential role in angiogenesis. Recent findings suggest that posttranslational proteolytic cleavage of VEGF receptors may be...
13.
Shaw S, Bollini S, Nader K, Gastaldello A, Mehta V, Filppi E, et al.
Cell Transplant
. 2017 Aug;
25(3):615.
PMID: 28836829
Long-term engraftment and phenotype correction has been difficult to achieve in humans after in utero stem cell transplantation mainly because of allogeneic rejection. Autologous cells could be obtained during gestation...
14.
15.
Swanson A, Rossi C, Ofir K, Mehta V, Boyd M, Barker H, et al.
Hum Gene Ther
. 2016 Aug;
27(12):997-1007.
PMID: 27530140
In a model of growth-restricted sheep pregnancy, it was previously demonstrated that transient uterine artery VEGF overexpression can improve fetal growth. This approach was tested in guinea-pig pregnancies, where placental...
16.
Mehta V, Ofir K, Swanson A, Kloczko E, Boyd M, Barker H, et al.
Reprod Sci
. 2016 Feb;
23(8):1087-95.
PMID: 26865541
Our study aimed to target adenoviral gene therapy to the uteroplacental circulation of pregnant guinea pigs in order to develop a novel therapy for fetal growth restriction. Four methods of...
17.
Pellet-Many C, Mehta V, Fields L, Mahmoud M, Lowe V, Evans I, et al.
Cardiovasc Res
. 2015 Sep;
108(2):288-98.
PMID: 26410366
Aims: Neuropilins 1 and 2 (NRP1 and NRP2) play crucial roles in endothelial cell migration contributing to angiogenesis and vascular development. Both NRPs are also expressed by cultured vascular smooth...
18.
Carr D, Mehta V, Wallace J, David A
Methods Mol Biol
. 2015 Aug;
1332:197-204.
PMID: 26285756
In this chapter, we describe a safe and effective approach to achieve local VEGF gene transfer to the uterine arteries in pregnant sheep using direct injection of viral vectors into...
19.
Mehta V, Carr D, Swanson A, David A
Methods Mol Biol
. 2015 Aug;
1332:189-96.
PMID: 26285755
In this chapter, we describe a novel method of adenoviral gene transfer to the uterine and radial arteries of pregnant guinea pigs to improve fetal growth. Adenoviruses encoding VEGF-A165 or...
20.
Mehta V, Abi-Nader K, Shangaris P, Shaw S, Filippi E, Benjamin E, et al.
PLoS One
. 2014 Jul;
9(6):e100021.
PMID: 24977408
Background: The normal development of the uteroplacental circulation in pregnancy depends on angiogenic and vasodilatory factors such as vascular endothelial growth factor (VEGF). Reduced uterine artery blood flow (UABF) is...