Vanessa Pirrone
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Explore the profile of Vanessa Pirrone including associated specialties, affiliations and a list of published articles.
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47
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779
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Recent Articles
1.
Garabet R, Dampier W, Tillman S, Malone K, Szep Z, Althoff A, et al.
J Neurovirol
. 2024 Jun;
30(4):423-433.
PMID: 38856821
Human immunodeficiency virus-associated neurocognitive disorders persist in the combination antiretroviral therapy era. CD4 nadir is a well-established predictor of cognition cross-sectionally, but its impact on longitudinal neurocognitive (NC) trajectories is...
2.
Grethlein D, Pirrone V, Devlin K, Dampier W, Szep Z, Winston F, et al.
Front Neurosci
. 2022 Sep;
16:912766.
PMID: 36090285
Significance: Existing screening tools for HIV-associated neurocognitive disorders (HAND) are often clinically impractical for detecting milder forms of impairment. The formal diagnosis of HAND requires an assessment of both cognition...
3.
Sullivan N, Dampier W, Chung C, Allen A, Atkins A, Pirrone V, et al.
Sci Rep
. 2019 Nov;
9(1):17088.
PMID: 31745112
The CRISPR/Cas9 system has been proposed as a cure strategy for HIV. However, few published guide RNAs (gRNAs) are predicted to cleave the majority of HIV-1 viral quasispecies (vQS) observed...
4.
Link R, Mele A, C Antell G, Pirrone V, Zhong W, Kercher K, et al.
Virus Res
. 2019 Aug;
272:197727.
PMID: 31437485
Human immunodeficiency virus type 1 (HIV-1) encodes for Tat, a multi-functional regulatory protein involved in transcriptional enhancement and in causing neurotoxicity/central nervous system (CNS) dysfunction. This study examines Sanger sequencing...
5.
Dampier W, Sullivan N, Mell J, Pirrone V, Ehrlich G, Chung C, et al.
AIDS Res Hum Retroviruses
. 2018 Jul;
34(11):950-960.
PMID: 29968495
The clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas9 system has been used to excise the HIV-1 proviral genome from latently infected cells, potentially offering a cure for HIV-infected patients....
6.
Rashad A, Song L, Holmes A, Acharya K, Zhang S, Wang Z, et al.
J Med Chem
. 2018 May;
61(11):5020-5033.
PMID: 29767965
To address the urgent need for new agents to reduce the global occurrence and spread of AIDS, we investigated the underlying hypothesis that antagonists of the HIV-1 envelope (Env) gp120...
7.
Mele A, Marino J, Chen K, Pirrone V, Janetopoulos C, Wigdahl B, et al.
Traffic
. 2018 May;
PMID: 29708629
The human immunodeficiency virus type 1 (HIV-1) transactivator of transcription (Tat) protein functions both intracellularly and extracellularly. Intracellularly, the main function is to enhance transcription of the viral promoter. However,...
8.
Liu Y, Nonnemacher M, Alexaki A, Pirrone V, Banerjee A, Li L, et al.
Clin Med Insights Pathol
. 2017 Nov;
10:1179555717694556.
PMID: 29162980
Previous studies have identified a CCAAT/enhancer binding protein (C/EBP) site located downstream of the transcriptional start site (DS3). The role of the DS3 element with respect to HIV-1 transactivation by...
9.
C Antell G, Dampier W, Aiamkitsumrit B, Nonnemacher M, Pirrone V, Zhong W, et al.
Int J Genomics
. 2017 Jun;
2017:4081585.
PMID: 28620613
Vpr is an HIV-1 accessory protein that plays numerous roles during viral replication, and some of which are cell type dependent. To test the hypothesis that HIV-1 tropism extends beyond...
10.
Banerjee A, Li L, Pirrone V, Krebs F, Wigdahl B, Nonnemacher M
Clin Med Insights Pathol
. 2017 May;
10:1179555717694535.
PMID: 28469516
CD34 hematopoietic progenitor cells have been shown to be susceptible to HIV-1 infection, possibly due to a low-level expression of CXCR4, a coreceptor for HIV-1 entry. Given these observations, we...