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Vanessa Ahmed

Explore the profile of Vanessa Ahmed including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 8
Citations 33
Followers 0
Related Specialties
Biochemistry
Chemistry
Endocrinology
Top 10 Co-Authors
Scott D Taylor
Yong Liu
Bryan Hill
Mehdi Ispahany
Nunzio Bottini
Mei-Jin Chen
Jennifer Lapierre
Stephanie M Stanford
Zaheer Ahmed
Cassandra Silvestro
Published In
Bioorg Med Chem
Bioorg Med Chem Lett
Antioxid Redox Signal
Anal Biochem
J Org Chem
Affiliations
Soon will be listed here.
Recent Articles
1.
Cellular biochemistry methods for investigating protein tyrosine phosphatases
Stanford S, Ahmed V, Barrios A, Bottini N
Antioxid Redox Signal . 2013 Dec; 20(14):2160-78. PMID: 24294920
Significance: The protein tyrosine phosphatases (PTPs) are a family of proteins that play critical roles in cellular signaling and influence many aspects of human health and disease. Although a wealth...
2.
Multiple pathways for the irreversible inhibition of steroid sulfatase with quinone methide-generating suicide inhibitors
Ahmed V, Liu Y, Taylor S
Chembiochem . 2009 May; 10(9):1457-61. PMID: 19466699
No abstract available.
3.
A re-examination of the difluoromethylenesulfonic acid group as a phosphotyrosine mimic for PTP1B inhibition
Hussain M, Ahmed V, Hill B, Ahmed Z, Taylor S
Bioorg Med Chem . 2008 Jun; 16(14):6764-77. PMID: 18555687
Protein tyrosine phosphatase 1B (PTP1B) is involved in the down-regulation of insulin signaling and is a well-validated therapeutic target for the treatment of diabetes and obesity. Key to the design...
4.
Enantioselective synthesis of protected L-4-[sulfonamido(difluoromethyl)]phenylalanine and L-4-[sulfonamido(methyl)]phenylalanine and an examination of hexa- and tripeptide platforms for evaluating pTyr mimics for PTP1B inhibition
Hill B, Ahmed V, Bates D, Taylor S
J Org Chem . 2006 Oct; 71(21):8190-7. PMID: 17025311
The first enantioselective syntheses of L-4-(sulfonamidomethyl)phenylalanine and L-[sulfonamido(difluoromethyl)]phenylalanine suitably protected for peptide syntheses are described. A key step in the synthesis of L-(sulfonamidomethyl)phenylalanine was an oxidative chlorination on Ac-L-Phe(4-CH2SCOCH3)-OEt to...
5.
Boronic acids as inhibitors of steroid sulfatase
Ahmed V, Liu Y, Silvestro C, Taylor S
Bioorg Med Chem . 2006 Sep; 14(24):8564-73. PMID: 16973364
Steroid sulfatase (STS) catalyzes the hydrolysis of steroidal sulfates such as estrone sulfate (ES1) to the corresponding steroids and inorganic sulfate. STS is considered to be a potential target for...
6.
Synthesis of a non-hydrolyzable estrone sulfate analogue bearing the difluoromethanesulfonamide group and its evaluation as a steroid sulfatase inhibitor
Liu Y, Ahmed V, Hill B, Taylor S
Org Biomol Chem . 2005 Sep; 3(18):3329-35. PMID: 16132094
Steroid sulfatase (STS) catalyzes the hydrolyis of steroidal sulfates such as estrone sulfate (ES1) and is considered to be an attractive target in the treatment of steroid dependent cancers. A...
7.
A fluorogenic substrate for the continuous assaying of aryl sulfatases
Ahmed V, Ispahany M, Ruttgaizer S, Guillemette G, Taylor S
Anal Biochem . 2005 Apr; 340(1):80-8. PMID: 15802133
The most common fluorogenic substrate for assaying aryl sulfatases (ARSs) is 4-methylumbelliferyl sulfate (MUS). However, ARSs operate optimally at pH values that are less than the pK(a) (7.8) of the...
8.
The difluoromethylene group as a replacement for the labile oxygen in steroid sulfates: a new approach to steroid sulfatase inhibitors
Lapierre J, Ahmed V, Chen M, Ispahany M, Guillemette J, Taylor S
Bioorg Med Chem Lett . 2003 Dec; 14(1):151-5. PMID: 14684318
Several estrone sulfate and estradiol sulfate analogues, in which the sulfate group was replaced with an alpha,alpha-difluoromethylenesulfonate group or an alpha,alpha-difluoromethylenetetrazole group, were examined as inhibitors of steroid sulfatase (STS)....