Valeriya Gaysinskaya
Overview
Explore the profile of Valeriya Gaysinskaya including associated specialties, affiliations and a list of published articles.
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10
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466
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Recent Articles
1.
Schratz K, Flasch D, Atik C, Cosner Z, Blackford A, Yang W, et al.
Cancer Cell
. 2023 Apr;
41(4):807-817.e6.
PMID: 37037617
Patients with short telomere syndromes (STS) are predisposed to developing cancer, believed to stem from chromosome instability in neoplastic cells. We tested this hypothesis in a large cohort assembled over...
2.
Schratz K, Gaysinskaya V, Cosner Z, DeBoy E, Xiang Z, Kasch-Semenza L, et al.
J Clin Invest
. 2021 Aug;
131(18).
PMID: 34343137
BACKGROUNDGermline mutations in telomerase and other telomere maintenance genes manifest in the premature aging short telomere syndromes. Myelodysplastic syndromes and acute myeloid leukemia (MDS/AML) account for 75% of associated malignancies,...
3.
Gaysinskaya V, Stanley S, Adam S, Armanios M
Chest
. 2020 Jul;
158(6):2449-2457.
PMID: 32710892
Background: Idiopathic pulmonary fibrosis (IPF) is the most common of short telomere phenotypes. Familial clustering of IPF is common, but the genetic basis remains unknown in more than one-half of...
4.
Gable D, Gaysinskaya V, Atik C, Talbot Jr C, Kang B, Stanley S, et al.
Genes Dev
. 2019 Sep;
33(19-20):1381-1396.
PMID: 31488579
Short telomere syndromes manifest as familial idiopathic pulmonary fibrosis; they are the most common premature aging disorders. We used genome-wide linkage to identify heterozygous loss of function of , a...
5.
Gaysinskaya V, Miller B, De Luca C, van der Heijden G, Hansen K, Bortvin A
Epigenetics Chromatin
. 2018 Apr;
11(1):15.
PMID: 29618374
Background: Meiosis is a specialized germ cell cycle that generates haploid gametes. In the initial stage of meiosis, meiotic prophase I (MPI), homologous chromosomes pair and recombine. Extensive changes in...
6.
Newkirk S, Lee S, Grandi F, Gaysinskaya V, Rosser J, Vanden Berg N, et al.
Proc Natl Acad Sci U S A
. 2017 Jun;
114(28):E5635-E5644.
PMID: 28630288
The PIWI-interacting RNA (piRNA) pathway is essential for retrotransposon silencing. In piRNA-deficient mice, L1-overexpressing male germ cells exhibit excessive DNA damage and meiotic defects. It remains unknown whether L1 expression...
7.
Gaysinskaya V, Bortvin A
Curr Protoc Cytom
. 2015 Apr;
72:7.44.1-7.44.24.
PMID: 25827485
Protocols for purification of murine male germ cells by FACS based on Hoechst 33342 (Ho342) dye staining have been reported and optimized. However, the protocols are often challenging to follow,...
8.
Gaysinskaya V, Soh I, van der Heijden G, Bortvin A
Cytometry A
. 2014 Mar;
85(6):556-65.
PMID: 24664803
Meiotic prophase I (MPI), is an initial stage of meiosis characterized by intricate homologous chromosome interactions, synapsis, and DNA recombination. These processes depend on the complex, but poorly understood early...
9.
Barson J, Karatayev O, Gaysinskaya V, Chang G, Leibowitz S
Regul Pept
. 2011 Sep;
173(1-3):13-20.
PMID: 21903140
While a high-fat diet when compared to low-fat diet is known to produce overeating and health complications, less is known about the effects produced by fat-rich diets differing in their...
10.
Chang G, Gaysinskaya V, Karatayev O, Leibowitz S
J Neurosci
. 2008 Nov;
28(46):12107-19.
PMID: 19005075
Recent studies in adult and weanling rats show that dietary fat, in close association with circulating lipids, can stimulate expression of hypothalamic peptides involved in controlling food intake and body...