Godfried W van der Heijden
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Explore the profile of Godfried W van der Heijden including associated specialties, affiliations and a list of published articles.
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29
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1259
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Recent Articles
1.
Oud M, de Leeuw N, Smeets D, Ramos L, van der Heijden G, Timmermans R, et al.
Andrology
. 2024 Aug;
PMID: 39180390
Background: Current guidelines indicate that patients with extreme oligozoospermia or azoospermia should be tested for chromosomal imbalances, azoospermia factor (AZF) deletions and/or CFTR variants. For other sperm abnormalities, no genetic...
2.
Wyrwoll M, van der Heijden G, Krausz C, Aston K, Kliesch S, McLachlan R, et al.
Nat Rev Urol
. 2023 Sep;
21(2):91-101.
PMID: 37723288
An increasing number of genes are being described in the context of non-syndromic male infertility. Linking the underlying genetic causes of non-syndromic male infertility with clinical data from patients is...
3.
Curfs M, Cohlen B, Slappendel E, Schoot D, Derhaag J, van Golde R, et al.
Hum Reprod
. 2023 Aug;
38(10):1952-1960.
PMID: 37646072
Study Question: Does assisted hatching increase the cumulative live birth rate in subfertile couples with repeated implantation failure? Summary Answer: This study showed no evidence of effect for assisted hatching...
4.
Wyrwoll M, Gaasbeek C, Golubickaite I, Stakaitis R, Oud M, Nagirnaja L, et al.
Am J Hum Genet
. 2022 Sep;
109(10):1850-1866.
PMID: 36150389
Infertility affects around 7% of the male population and can be due to severe spermatogenic failure (SPGF), resulting in no or very few sperm in the ejaculate. We initially identified...
5.
Riera-Escamilla A, Vockel M, Nagirnaja L, Xavier M, Carbonell A, Moreno-Mendoza D, et al.
Am J Hum Genet
. 2022 Jul;
109(8):1458-1471.
PMID: 35809576
Although the evolutionary history of the X chromosome indicates its specialization in male fitness, its role in spermatogenesis has largely been unexplored. Currently only three X chromosome genes are considered...
6.
Nagirnaja L, Morup N, Nielsen J, Stakaitis R, Golubickaite I, Oud M, et al.
N Engl J Med
. 2021 Aug;
385(8):707-719.
PMID: 34347949
Background: P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are short (21 to 35 nucleotides in length) and noncoding and are found almost exclusively in germ cells, where they regulate aberrant expression...
7.
Wyrwoll M, Temel S, Nagirnaja L, Oud M, Lopes A, van der Heijden G, et al.
Am J Hum Genet
. 2020 Jul;
107(2):342-351.
PMID: 32673564
Male infertility affects ∼7% of men, but its causes remain poorly understood. The most severe form is non-obstructive azoospermia (NOA), which is, in part, caused by an arrest at meiosis....
8.
Malki S, van der Heijden G, ODonnell K, Martin S, Bortvin A
Dev Cell
. 2019 Dec;
51(5):658.
PMID: 31794719
No abstract available.
9.
Gaysinskaya V, Miller B, De Luca C, van der Heijden G, Hansen K, Bortvin A
Epigenetics Chromatin
. 2018 Apr;
11(1):15.
PMID: 29618374
Background: Meiosis is a specialized germ cell cycle that generates haploid gametes. In the initial stage of meiosis, meiotic prophase I (MPI), homologous chromosomes pair and recombine. Extensive changes in...
10.
Federici F, Mulugeta E, Schoenmakers S, Wassenaar E, Hoogerbrugge J, van der Heijden G, et al.
BMC Genomics
. 2015 Apr;
16:291.
PMID: 25884295
Background: In mammalian meiotic prophase, homologous chromosome recognition is aided by formation and repair of programmed DNA double-strand breaks (DSBs). Subsequently, stable associations form through homologous chromosome synapsis. In male...