Val Millar
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Explore the profile of Val Millar including associated specialties, affiliations and a list of published articles.
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20
Citations
354
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Recent Articles
11.
Leng T, Akther H, Hackstein C, Powell K, King T, Friedrich M, et al.
Cell Rep
. 2019 Sep;
28(12):3077-3091.e5.
PMID: 31533032
MAIT cells are an unconventional T cell population that can be activated through both TCR-dependent and TCR-independent mechanisms. Here, we examined the impact of combinations of TCR-dependent and TCR-independent signals...
12.
McDermott L, Weir G, Themistocleous A, Segerdahl A, Blesneac I, Baskozos G, et al.
Neuron
. 2019 Feb;
101(5):905-919.e8.
PMID: 30795902
Loss-of-function mutations in Na1.7 cause congenital insensitivity to pain (CIP); this voltage-gated sodium channel is therefore a key target for analgesic drug development. Utilizing a multi-modal approach, we investigated how...
13.
Hernando-Rodriguez B, Erinjeri A, Rodriguez-Palero M, Millar V, Gonzalez-Hernandez S, Olmedo M, et al.
BMC Biol
. 2018 Mar;
16(1):36.
PMID: 29598825
Background: Advances in automated image-based microscopy platforms coupled with high-throughput liquid workflows have facilitated the design of large-scale screens utilising multicellular model organisms such as Caenorhabditis elegans to identify genetic...
14.
Ong J, Serra M, Segal J, Cujba A, Ng S, Butler R, et al.
Stem Cell Reports
. 2018 Feb;
10(3):693-702.
PMID: 29478892
Use of hepatocytes derived from induced pluripotent stem cells (i-Heps) is limited by their functional differences in comparison with primary cells. Extracellular niche factors likely play a critical role in...
15.
Boucanova F, Maia A, Cruz A, Millar V, Mendes Pinto I, Relvas J, et al.
J Neurosci Methods
. 2017 Nov;
294:122-135.
PMID: 29174019
Background: Oligodendrocytes (OL) are the myelinating cells of the central nervous system. OL differentiation from oligodendrocyte progenitor cells (OPC) is accompanied by characteristic stereotypical morphological changes. Quantitative imaging of those...
16.
Hoffman E, Patel A, Ball D, Klapwijk J, Millar V, Kumar A, et al.
Pharm Res
. 2017 May;
34(12):2466-2476.
PMID: 28540501
Purpose: Progress to the clinic may be delayed or prevented when vacuolated or "foamy" alveolar macrophages are observed during non-clinical inhalation toxicology assessment. The first step in developing methods to...
17.
Clements M, Millar V, Williams A, Kalinka S
Toxicol Sci
. 2015 Aug;
148(1):241-60.
PMID: 26259608
More relevant and reliable preclinical cardiotoxicity tests are required to improve drug safety and reduce the cost of drug development. Current in vitro testing strategies predominantly take the form of...
18.
Hoffman E, Kumar A, Kanabar V, Arno M, Preux L, Millar V, et al.
Mol Pharm
. 2015 May;
12(8):2675-87.
PMID: 25941945
Although foamy macrophages (FMΦ) are commonly observed during nonclinical development of medicines for inhalation, there are no accepted criteria to differentiate adaptive from adverse FMΦ responses in drug safety studies....
19.
Rees P, Wills J, Brown M, Tonkin J, Holton M, Hondow N, et al.
Nat Methods
. 2014 Sep;
11(11):1177-81.
PMID: 25218182
For phenotypic behavior to be understood in the context of cell lineage and local environment, properties of individual cells must be measured relative to population-wide traits. However, the inability to...
20.
Yau C, Pascu S, Odom S, Warren J, Klotz E, Frampton M, et al.
Chem Commun (Camb)
. 2008 Jun;
(25):2897-9.
PMID: 18566717
The crystal structure of a cyanine dye rotaxane shows that the cyclodextrin is tightly threaded round the polymethine bridge of the dye; encapsulation dramatically increases the kinetic chemical stability of...