John B Davis
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Explore the profile of John B Davis including associated specialties, affiliations and a list of published articles.
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53
Citations
2045
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Recent Articles
1.
OBrien D, Jones H, Shi Y, Guenther F, Vendrell I, Viner R, et al.
J Proteome Res
. 2025 Jan;
24(2):479-490.
PMID: 39804742
Inhibition of the mitochondrial deubiquitinating (DUB) enzyme USP30 is neuroprotective and presents therapeutic opportunities for the treatment of idiopathic Parkinson's disease and mitophagy-related disorders. We integrated structural and quantitative proteomics...
2.
OBrien D, Jones H, Guenther F, Murphy E, England K, Vendrell I, et al.
Mol Cell Proteomics
. 2023 Jun;
22(8):100609.
PMID: 37385347
Dampening functional levels of the mitochondrial deubiquitylating enzyme Ubiquitin-specific protease 30 (USP30) has been suggested as an effective therapeutic strategy against neurodegenerative disorders such as Parkinson's Disease. USP30 inhibition may...
3.
Williamson M, Madureira M, McGuinness W, Heon-Roberts R, Mock E, Naidoo K, et al.
Hum Mol Genet
. 2023 Jun;
32(18):2808-2821.
PMID: 37384414
Mutations in the Leucine-Rich Repeat Kinase 2 (LRRK2) gene have been identified as one of the most common genetic causes of Parkinson's disease (PD). The LRRK2 PD-associated mutations LRRK2G2019S and...
4.
Carling P, Ryan B, McGuinness W, Kataria S, Humble S, Milde S, et al.
Autophagy
. 2022 Jul;
19(2):692-705.
PMID: 35786165
The accumulation of toxic protein aggregates in multiple neurodegenerative diseases is associated with defects in the macroautophagy/autophagy-lysosome pathway. The amelioration of disease phenotypes across multiple models of neurodegeneration can be...
5.
Nizami S, Millar V, Arunasalam K, Zarganes-Tzitzikas T, Brough D, Tresadern G, et al.
Sci Rep
. 2021 Oct;
11(1):20529.
PMID: 34635690
No abstract available.
6.
Obst J, Hall-Roberts H, Smith T, Kreuzer M, Magno L, Di Daniel E, et al.
Sci Rep
. 2021 Oct;
11(1):19842.
PMID: 34615897
Human genetic studies have linked rare coding variants in microglial genes, such as TREM2, and more recently PLCG2 to Alzheimer's disease (AD) pathology. The P522R variant in PLCG2 has been...
7.
Nizami S, Millar V, Arunasalam K, Zarganes-Tzitzikas T, Brough D, Tresadern G, et al.
Sci Rep
. 2021 Jul;
11(1):15319.
PMID: 34321581
Inhibition of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome has recently emerged as a promising therapeutic target for several inflammatory diseases. After priming and activation by inflammation...
8.
Szykowska A, Chen Y, Smith T, Preger C, Yang J, Qian D, et al.
Structure
. 2021 Jul;
29(11):1241-1252.e5.
PMID: 34233201
Mutations in TREM2, a receptor expressed by microglia in the brain, are associated with an increased risk of neurodegeneration, including Alzheimer's disease. Numerous studies support a role for TREM2 in...
9.
Swanton T, Beswick J, Hammadi H, Morris L, Williams D, De Cesco S, et al.
Chem Sci
. 2021 Jun;
11(43):11720-11728.
PMID: 34094411
The NLRP3 inflammasome regulates production of the pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18, and contributes to inflammation exacerbating disease. Fenamate non-steroidal anti-inflammatory drugs (NSAIDs) were recently described as NLRP3 inflammasome...
10.
In vitro Quantitative Imaging Assay for Phagocytosis of Dead Neuroblastoma Cells by iPSC-Macrophages
Hall-Roberts H, Di Daniel E, James W, Davis J, Cowley S
J Vis Exp
. 2021 Mar;
(168).
PMID: 33645588
Microglia orchestrate neuroimmune responses in several neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease. Microglia clear up dead and dying neurons through the process of efferocytosis, a specialized form of...