Val A Fajardo
Overview
Explore the profile of Val A Fajardo including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
67
Citations
619
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Rahbani J, Bunk J, Lagarde D, Samborska B, Roesler A, Xiao H, et al.
Cell Metab
. 2024 Jan;
36(3):526-540.e7.
PMID: 38272036
That uncoupling protein 1 (UCP1) is the sole mediator of adipocyte thermogenesis is a conventional viewpoint that has primarily been inferred from the attenuation of the thermogenic output of mice...
12.
Li K, Desai R, Scott R, Steele J, Machado M, Demharter S, et al.
NPJ Microgravity
. 2023 Dec;
9(1):90.
PMID: 38092777
The adverse effects of microgravity exposure on mammalian physiology during spaceflight necessitate a deep understanding of the underlying mechanisms to develop effective countermeasures. One such concern is muscle atrophy, which...
13.
Stoikos J, Kurgan N, Kottaras S, Fajardo V, Gittings W, Klentrou P
Can J Physiol Pharmacol
. 2023 Nov;
102(4):293-304.
PMID: 37976473
Sclerostin, a potent inhibitor of the Wnt signaling pathway, plays a critical role in bone homeostasis. Evidence suggests that sclerostin may also be involved in crosstalk between other tissues, including...
14.
Baranowski R, Braun J, Hockey B, Yumol J, Geromella M, Watson C, et al.
iScience
. 2023 Jun;
26(7):107047.
PMID: 37360691
We examined the effects of ∼30 days of spaceflight on glycogen synthase kinase 3 (GSK3) content and inhibitory serine phosphorylation in murine muscle and bone samples from four separate missions...
15.
Baranowski B, Mohammad A, Finch M, Brown A, Dhaliwal R, Marko D, et al.
J Appl Physiol (1985)
. 2023 Jun;
135(1):121-135.
PMID: 37262102
Exercise reduces cognitive aging, neurodegeneration, and Alzheimer's disease (AD) risk. Acute exercise reduces the activity of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1), the rate-limiting enzyme in the production of...
16.
Kurgan N, Baranowski B, Stoikos J, MacNeil A, Fajardo V, MacPherson R, et al.
Front Physiol
. 2023 Jan;
13:1061715.
PMID: 36685192
It is well established that sclerostin antagonizes the anabolic Wnt signalling pathway in bone, however, its physiological role in other tissues remains less clear. This study examined the effect of...
17.
Hunter K, Crozier R, Braun J, Fajardo V, MacNeil A
FASEB J
. 2023 Jan;
37(2):e22748.
PMID: 36624659
Mast cells are granulocytic immune sentinels present in vascularized tissues that drive chronic inflammatory mechanisms characteristic of allergic pathologies. IgE-mediated mast cell activation leads to a rapid mobilization of Ca...
18.
Crozier R, Yousef M, Coish J, Fajardo V, Tsiani E, MacNeil A
J Biol Chem
. 2023 Jan;
299(4):102867.
PMID: 36608933
Mast cells are essential regulators of inflammation most recognized for their central role in allergic inflammatory disorders. Signaling via the high-affinity immunoglobulin E (IgE) receptor, FcεRI, leads to rapid degranulation...
19.
Kurgan N, Stoikos J, Baranowski B, Yumol J, Dhaliwal R, Sweezey-Munroe J, et al.
J Bone Miner Res
. 2023 Jan;
38(4):541-555.
PMID: 36606556
Sclerostin is an inhibitor of the osteogenic Wnt/β-catenin signaling pathway that also has an endocrine role in regulating adipocyte differentiation and metabolism. Additionally, subcutaneous white adipose tissue (scWAT) sclerostin content...
20.
Geromella M, Braun J, Fajardo V
STAR Protoc
. 2023 Jan;
4(1):101987.
PMID: 36602905
This protocol employs the indo-1 Ca fluorophore to quantify Ca uptake by the sarco(endo)plasmic reticulum Ca ATPase pump in murine muscle homogenates and allows for real-time kinetic measurement of Ca...