Adam J MacNeil
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Explore the profile of Adam J MacNeil including associated specialties, affiliations and a list of published articles.
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52
Citations
391
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Recent Articles
1.
Coish J, MacNeil L, MacNeil A
Microbes Infect
. 2024 Dec;
:105464.
PMID: 39662700
Antibody-dependent enhancement (ADE) is an immunological paradox whereby sensitization following a primary viral infection results in the subsequent enhancement of a similar secondary infection. This idiosyncratic immune response has been...
2.
Marcella B, Hockey B, Braun J, Whitley K, Geromella M, Baranowski R, et al.
Nat Commun
. 2024 Nov;
15(1):10210.
PMID: 39587049
Inhibiting glycogen synthase kinase 3 (GSK3) improves muscle function, metabolism, and bone health in many diseases and conditions; however, whether GSK3 should be targeted for Duchenne muscular dystrophy (DMD), a...
3.
Kalailingam P, Mohd-Kahliab K, Ngan S, Iyappan R, Melekh E, Lu T, et al.
EMBO Mol Med
. 2023 Nov;
15(12):e18526.
PMID: 37971164
Aging results from the accumulation of molecular damage that impairs normal biochemical processes. We previously reported that age-linked damage to amino acid sequence NGR (Asn-Gly-Arg) results in "gain-of-function" conformational switching...
4.
Baranowski R, Braun J, Hockey B, Yumol J, Geromella M, Watson C, et al.
iScience
. 2023 Jun;
26(7):107047.
PMID: 37360691
We examined the effects of ∼30 days of spaceflight on glycogen synthase kinase 3 (GSK3) content and inhibitory serine phosphorylation in murine muscle and bone samples from four separate missions...
5.
Hicks N, Crozier R, MacNeil A
J Leukoc Biol
. 2023 May;
114(1):92-105.
PMID: 37141385
Mast cells are leukocytes that mediate various aspects of immunity and drive allergic hypersensitivity pathologies. Mast cells differentiate from hematopoietic progenitor cells in a manner that is largely IL-3 dependent....
6.
Dempster K, OLeary D, MacNeil A, Wade T
Am J Physiol Heart Circ Physiol
. 2023 Mar;
324(6):H791-H803.
PMID: 36961488
The effect of adverse childhood experiences (ACEs) on left ventricular mass (LVM) and left ventricular function remains largely unknown across the lifespan. This study investigated the influence of ACEs on...
7.
Dempster K, Wade T, MacNeil A, OLeary D
Am J Physiol Regul Integr Comp Physiol
. 2023 Jan;
324(3):R425-R434.
PMID: 36693169
Adverse childhood experiences (ACEs) are associated with greater prevalence of cardiovascular disease and altered acute stress reactivity. The current study investigated the effect of ACEs on hemodynamic and autonomic responses...
8.
Kurgan N, Baranowski B, Stoikos J, MacNeil A, Fajardo V, MacPherson R, et al.
Front Physiol
. 2023 Jan;
13:1061715.
PMID: 36685192
It is well established that sclerostin antagonizes the anabolic Wnt signalling pathway in bone, however, its physiological role in other tissues remains less clear. This study examined the effect of...
9.
Hunter K, Crozier R, Braun J, Fajardo V, MacNeil A
FASEB J
. 2023 Jan;
37(2):e22748.
PMID: 36624659
Mast cells are granulocytic immune sentinels present in vascularized tissues that drive chronic inflammatory mechanisms characteristic of allergic pathologies. IgE-mediated mast cell activation leads to a rapid mobilization of Ca...
10.
Crozier R, Yousef M, Coish J, Fajardo V, Tsiani E, MacNeil A
J Biol Chem
. 2023 Jan;
299(4):102867.
PMID: 36608933
Mast cells are essential regulators of inflammation most recognized for their central role in allergic inflammatory disorders. Signaling via the high-affinity immunoglobulin E (IgE) receptor, FcεRI, leads to rapid degranulation...